Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-624-6 | CAS number: 123-39-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Comparable to Guideline study with acceptable restrictions (partly limited documentation, e.g. no further details on the test substance or onset of clinical symptoms; max technical feasible concentration used [limit concentration according to OECD 403 is 5 mg/l; minor restriction]).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- monomethylformamide
- IUPAC Name:
- monomethylformamide
- Details on test material:
- Purity: 99.7%
no further details
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source: Firma WIGA, Sulzfeld,
Initial body weight: 200 +- 30g
After exposure certified diet and tap water ad libitum
no further details
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: air
- Details on inhalation exposure:
- Aerosol generation:
Constant supply of the liquid test substance to a nozzle via an infusion pump and generation of aerosol via compressed air (2.5 bar) which was fed to the nozzle. Inhalation system fed with the aerosol (slight over-pressure of 1 Pa).
Samples (3 l/minutes, total volume 5 l; near the head of animals) analysed by GC methods. Data of 4 samples were given (mean value in the result section) - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Nominal 24.1 mg/l
Analytical value (mean): 4.1 mg/l - No. of animals per sex per dose:
- 10
- Control animals:
- other: not required
- Details on study design:
- Post exposure observation period 14 days
Clinical symptoms recorded daily
Body weight measured day 0, 7, 14
Necropsy performed - Statistics:
- not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4.1 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- 0/10 females and 0/10 males
- Clinical signs:
- other: watery or bloody secretion from the nose increased respiration rate ruffled coat prone position all effects reversible within 6 days
- Body weight:
- clearly reduced body weight gain in males, slight reduction in females
- Gross pathology:
- no effects
- Other findings:
- no
Applicant's summary and conclusion
- Conclusions:
- The LC50 (4 h) in male and female Sprague-Dawley rats is > 4.1 mg/l (1670 ppm).
- Executive summary:
omparable to Guideline study with acceptable restrictions (partly limited documentation, e.g. no further details on the test substance or onset of clinical symptoms; max technical feasible concentration used [limit concentration according to OECD 403 is 5 mg/l; minor restriction]).
Ten female and 10 male Sprague-Dawley rats were exposed to an aerosol for 4 h (head only exposure), the analytical concentration was 4.1 mg/l (nominal 24.1 mg/l). Body weight was measured at day 0, 7, and 14. The clinical symptoms were recorded daily. After the post exposure period of 14 days the rats were necropsied.
No mortality was found. Authors reported watery or bloody secretion from the nose, increased respiration rate, ruffled coat, and prone position. All effects were reversible within 6 days. Clearly reduced body weight gain was seen in males, slight reduction in females. No effects were detected at necropsy.
Conclusion: The LC50 (4 h) in male and female Sprague-Dawley rats is > 4.1 mg/l (1670 ppm).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
