Registration Dossier
Registration Dossier
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EC number: 415-670-3 | CAS number: 78850-37-0 GR138766X
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Nature of substance: Solid
Constituent 1
Test animals / tissue source
- Species:
- other: New Zealand White rabbites
Test system
- Amount / concentration applied:
- 10 MG
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritant / corrosive response data:
- Reversibility of any observed effect: Changes fully reversible within 3 days
Reversibility of any observed effect: Changes not fully reversible within 7 days - Other effects:
- Slight corneal and mild conjunctival reations were noted.
One treated eye returned to normal 72 hours after treatment
and the other two treated eyes had returned to normal seven
days after treatment.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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