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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
Nature of substance: Solid

Test animals / tissue source

Species:
other: New Zealand White rabbites

Test system

Amount / concentration applied:
10 MG
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
animal #1
Remarks:
(mean score 1)
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Irritation parameter:
conjunctivae score
Remarks:
(redness)
Basis:
animal #2
Remarks:
(mean score 2)
Time point:
other: overall at 24, 48 and 72 h
Score:
0
Irritant / corrosive response data:
Reversibility of any observed effect: Changes fully reversible within 3 days
Reversibility of any observed effect: Changes not fully reversible within 7 days
Other effects:
Slight corneal and mild conjunctival reations were noted.
One treated eye returned to normal 72 hours after treatment
and the other two treated eyes had returned to normal seven
days after treatment.

Applicant's summary and conclusion

Interpretation of results:
other: not classified

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