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EC number: 214-068-6 | CAS number: 1076-97-7
The study was performed to investigate the potential of 1,4-cyclohexanedicarboxylic Acid (1,4-CHDA) to induce mutations at the mouse lymphoma thymidine kinase locus using the cell line L5178Y. The assay was performed in two independent experiments, using two parallel cultures each. The first main experiment was performed with and without liver microsomal activation and a treatment period of 4 h. The second experiment was solely performed in the absence of metabolic activation with a treatment period of 24 hours. The highest applied concentration (1800 μg/mL) was chosen with regard to the molecular weight of the test item corresponding to a molar concentration of about 10 mM. No substantial and reproducible dose dependent increase in mutant colony numbers was observed in both main experiments. No relevant shift of the ratio of small versus large colonies was observed up to the maximal concentration of the test item. Appropriate reference mutagens were used as positive controls and showed a distinct increase in induced mutant colonies, indicating that the tests were sensitive and valid.
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