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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20/2/2016 - 20/2/2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to
Guideline:
other: Shake Flask Method
Principles of method if other than guideline:
The water solubility determination of test item was done as per the shake flask method
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
- Name of test material : 5-methoxy-1,3-dihydro-2H-benzimidazole-2-thione
- Molecular formula : C8H8N2OS
- Molecular weight : 180.2302 g/mol
- Smiles notation : COc1ccc2c(c1)nc([nH]2)S
- InChl : 1S/C8H8N2OS/c1-11-5-2-3-6-7(4-5)10-8(12)9-6/h2-4H,1H3,(H2,9,10,12)
- Substance type : Organic
- Physical state : Solid
Key result
Water solubility:
320 mg/L
Conc. based on:
test mat.
Temp.:
25 °C
pH:
5.88
Remarks on result:
other: No other detail available

TEST DESCRIPTION AND RESULT

Quantity of the required for formation of saturated solution test item

(mg/g)

Volume of water taken

(mL)

Temperature at which the testing performed

(°C)

Procedures undertaken

Water solubility Value / Range

(in g/L)

pH of test solution

 

 

100 mg

 

 

 

50ml

 

 

25 °C

Mechanical Stirring

3Hrs

 

320 mg/L

 

5.88

Membrane filtration

Yes performed

 

Air Drying

03 hrs

 

Conclusions:
The water solubility determination of test item was done gravimetrically as per the shake flask method using membrane filtration followed by air drying.The water solubility was determine to be 320 mg/L at 25°C. Thus the chemical is considered to be moderately soluble.
Executive summary:

The water solubility determination of test item was done gravimetrically as per the shake flask method using membrane filtration followed by air drying.The water solubility was determine to be 320 mg/L at 25°C. Thus the chemical is considered to be moderately soluble.

Description of key information

The water solubility determination of test item was done gravimetrically as per the shake flask method using membrane filtration followed by air drying.The water solubility was determine to be 320 mg/L at 25°C.Thus the chemical is considered to be moderately soluble.

Key value for chemical safety assessment

Water solubility:
320 mg/L
at the temperature of:
25 °C

Additional information

The water solubility determination of test item was done gravimetrically as per the shake flask method using membrane filtration followed by air drying.The water solubility was determine to be 320 mg/L at 25°C.Thus the chemical is considered to be moderately soluble.