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EC number: 617-834-1 | CAS number: 863329-69-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Mar - Apr 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD guideline under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 7α-bromo-5,6β-epoxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one
- EC Number:
- 617-834-1
- Cas Number:
- 863329-69-5
- Molecular formula:
- C25H35BrO4
- IUPAC Name:
- 7α-bromo-5,6β-epoxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one
- Details on test material:
- - Name of test material (as cited in study report): Bromepoxid (ZK137314)
- Analytical purity:
- Lot/batch No.:
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 10 mg/L
- Based on:
- test mat.
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Degradation of reference compound: 83%
Degradation of toxicity control: 47%
Any other information on results incl. tables
Biological degradation (cumulative) in percent (corrected for blank C02-production) of ZK 137314
Test | Nominal | Day of sampling | ||||||
compound | concentration | |||||||
of carbon | 4 | 7 | 11 | 16 | 21 | 25 | 30 | |
ZK 137314 | 10 mg/L | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sodium acetate | 10 mg/L | 24 | 43 | 59 | 71 | 77 | 80 | 83 |
(reference) | ||||||||
ZK 137314 + | 10 mg/L + | 13 | 22 | 31 | 38 | 42 | 44 | 47 |
sodium acetate | 10 mg/L | |||||||
(toxicity control) |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The test compound ZK 137314 was not degraded by day 30 (28 days of incubation).
- Executive summary:
The purpose of this study was to determine the ready biodegradability of ZK 137314, an intermediate of the synthesis of drospirenone. The study was conducted in agreement with the following test guideline: OECD guideline for testing of chemicals, Ready biodegradability: CO2-evolution test, no. 301 B.
The test substance ZK 137314 was incubated in a concentration of 10 mg carbon/I in triplicate in an aqueous solution including nutrients with micraorganisms fram a municipal sewage treatment plant for 28 days. The biological degradation of the test and reference substances was evaluated by measurement of the carbon dioxide (CO2) produced during the test period.
The test compound ZK 137314 was not degraded by day 30 (28 days of incubation). The reference compound sodium acetate was degraded to 83% on day 30 (28 days of incubation). In the toxicity control, the reference compound (sodium acetate) plus the test compound ZK 137314 was degraded up to 47% on day 30 (28 days of incubation), thus reflecting the degradation of the substances incubated separately.
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