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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016-07-22 to 2016-07-27
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
Powder samples are analysed by laser diffraction using the internal method SOP-017 “Particle Size Distribution by Laser Diffraction”. The technique for laser diffraction analysis is adopted from ISO 13320:2009 “Particle size analysis – Laser diffraction methods”.
Iron (III) Oxide was used as a proxy for density and refractive index data for the laser diffraction measurements (5.242 g/cm3 and 2.42 respectively).
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Key result
Percentile:
other: D[4,3] Volume or mass moment mean (De Brouckere mean diameter)
Mean:
155.47 µm
Remarks on result:
other: standard deviation not available
Key result
Percentile:
D10
Mean:
68.83 µm
St. dev.:
0.83
Key result
Percentile:
D50
Mean:
145.67 µm
St. dev.:
0.86
Key result
Percentile:
D90
Mean:
ca. 260.33 µm
St. dev.:
0.96
Key result
Percentile:
other: % volume below 9.86 µm
Mean:
ca. 0.74 other: %
Remarks on result:
other: standard deviation not available
Conclusions:
PSD was analysed by laser diffraction using the internal method SOP-017 “Particle Size Distribution by Laser Diffraction”. The technique for laser diffraction analysis is adopted from ISO 13320:2009 “Particle size analysis – Laser diffraction methods”.
The Volume or mass moment mean (De Brouckere mean diameter) was measured at 155.67 µm.
Volume diameters where 10, resp. 50, resp. 90 percent of the distribution is smaller were measured at 68.83 µm, resp. 145.67 µm, resp. 260.33 µm.
% volume below 9.86 μm is 0.74 %.
Weighted Respirable Fraction (SWeRF) was reported as 0.0 %.
Executive summary:

Particle size distribution was measured and reported by distribution plots; volume-rated with Size Weighted Respirable Fraction (SWeRF).

The Volume or mass moment mean (De Brouckere mean diameter) was measured at 155.67 µm.

Weighted Respirable Fraction (SWeRF) was reported as 0.0 %.

Description of key information

The D50 of the substance is 145.67 µm, the D90 is 260.33 µm (IOM, 2016).

Additional information