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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

None of the category members has an oral or dermal LD50 < 2000 mg/kg bw. Inhalation effects are not expected among category members, because no exposure is expected basing on the low vapour pressure of the substances.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
Adipic acid diesters category. See attached report.
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
not specified
Remarks on result:
other: Non of the category members with acute oral toxicity data has a LD50 lower than 5000 mg/kg bw
Interpretation of results:
not classified
Remarks:
Migrated information
Conclusions:
Non of the category members with acute oral toxicity data has a LD50 lower than 5000 mg/kg bw.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
Adipic acid diesters category. See attached report.
Duration of exposure:
h
Remarks on result:
not measured/tested
Conclusions:
All category members have a very low vapour pressure, therefore human exposure via inhalation is not foreseen. However, no molrtality was observed in rats exposed to air saturated with bis(2-ethylhexyl)adipate and with dibutyl adipate.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
Adipi acid diesters category. See attached report.
Key result
Effect level:
> 2 000 mg/kg bw
Remarks on result:
not determinable due to absence of adverse toxic effects
Interpretation of results:
GHS criteria not met
Conclusions:
None of the category members has a dermal LD50 lower than 2000 mg/kg bw.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 000 mg/kg bw

Additional information

Justification for classification or non-classification

Basing on the available acute toxicity data, based on a read-across approach with the adipic acid diesters category, bis[2-[2-(2-butoxyethoxy)ethoxy]ethyl]adipate is not classified for acute toxicity according to Regulation (EC) n. 1272/2008.