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Short-term toxicity to fish

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Description of key information

96h LC50 (Pimephales promelas) = 29 mg/L (measured concentration, freshwater, OECD 203)
96h LC50 (Cyprinodon variegates) = 4.1 mg/L (measured concentration, marine water, ASTM E-35 1980)

Key value for chemical safety assessment

LC50 for freshwater fish:
29 mg/L
LC50 for marine water fish:
4.1 mg/L

Additional information

One GLP compliant study investigating effects of C12-isoAS Na (CAS 94200-74-5) is available (Mitterer 1998). The test was performed with golden orfe fish (Leuciscus idus) according to OECD guideline 203. Mortality of fish caused by the test substance was determined after 24, 48, 72 and 96 hours of exposure to the nominal test concentration of 100 mg/L in a limit test. No analytical measurement of test concentration is available. The results showed that the 96-hour LC50 value was above 100 mg/L (nominal concentration). However, available short-term toxicity testing with another C12 homologue CAS 151-21-3 shows stronger toxic effects (Rawlings 2004). Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5, a read-across to this structurally related category member was conducted and the study of Rawlings is considered as a key study. Toxic effects of CAS 151-21-3 to fathead minnow (Pimephales promelas) were studied in a non-GLP test performed according to OECD 203 guideline. Fish were exposed in a flow-through system to five test concentrations up to 48 mg/L of nominal concentration, corresponding to 40 mg/L of measured concentration. Mortality of fish was evaluated every 24 hours. The test substance was determined to have the 96-hour LC50 value of 29 mg/L (measured concentration). Moreover, the short term effects of CAS 151-21-3 were studied on the marine sheepshead minnow Cyprinodon variegatus (Roberts et al. 1982). This non-GLP test was performed according to ASTM E-35 (1980) method. Fish were exposed to five test concentrations in brackish water (salinity 10 ‰) under static conditions. The 96h LC50 value of 4.1 mg/L was determined (measured concentration).

Due to structural and property similarities with the tested category member, it can be concluded that the above results also apply to C12-isoAS Na (CAS 94200-74-5).