Registration Dossier
Registration Dossier
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EC number: 403-700-8 | CAS number: 2687-94-7 NOP; SURFADONE LP-100 SURFACTANT
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Two in vitro studies of genotoxicty - one on bacteria and one on mammalian cells - are submitted. Both give a negative result. An additional in vivo study on genotoxicty - a micronucleas assay - is submitted. This also gives a negative result.
It is concluded that N-(n-octyl)-2-pyrrolidinone is not genotoxic.
Justification for selection of genetic toxicity endpoint
The study has been completed to modern guidelines, and to GLP standards.
Short description of key information:
N-(n-octyl)-2-pyrrolidinone is found not to have any genotoxic potential.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No classification is required since both studies show N-(n-octyl)-2-pyrrolidinone does not have genotoxic potential.
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