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Diss Factsheets
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EC number: 700-887-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral LD50 in several species such as rats for potassium chloride and l-alanyl-l-glutamine were always above 2000 mg/kg. The dermal LD50 for L-alanyl-L-glutamine was also >2000 mg/kg in rabbits. As potassium chloride in the absence of published data or studies is not expected to induce acute dermal toxicity, the reaction mass of L-alanyl-L-glutamine and potassium chlroide is also considered as not classified regarding acute dermal toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- mg/kg bw
- Quality of whole database:
- The studies or publications contributing to this endpoint conclusion are partly not reporting on investigations conducted according to guidelines and GLP regulations, but are covering the most relevant endpoints such as mortality and post-mortem examinations. Therefore they are considered to be usable for the overall classification of the substance regarding its acute oral toxicity. Both main ingredients of reaction mass of l-analyl-l-glutamine and potassium chloride were tested individually, but no synergistic or antagonistic activity is expected.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- mg/kg bw
- Quality of whole database:
- The studies or publications contributing to this endpoint conclusion are partly not reporting on investigations conducted according to guidelines and GLP regulations, but are covering the most relevant endpoints such as mortality and post-mortem examinations. Therefore they are considered to be usable for the overall classification of the substance regarding its acute oral toxicity. Both main ingredients of reaction mass of l-analyl-l-glutamine and potassium chloride were tested individually, but no synergistic or antagonistic activity is expected.
Additional information
No data is available on the acute oral toxicity to rodents of the reaction mass of L-Alanyl-L-glutamine and potassium chloride.
The substance consists of two components namely the dipeptide L-Alanyl-L-glutamine and the salt potassium chloride.
Besides these two main components only non-hazardous / non-classified amino acids in small amounts are present. Based on the composition of the substance it can be assumed that the results obtained with the individual main components (L-Alanyl-L-glutamine and potassium chloride) apply likewise to the test material under investigation (reaction mass of L-Alanyl-L-glutamine and potassium chloride). Therefore read-across data for the dipeptide L-Alanyl-L-glutamine and the salt potassium chloride is provided. Both substances showed LD50 values above 2000 mg/kg body weight for dermal and oral acute toxicity and therefore do not have to be classified.
Justification for selection of acute toxicity – dermal endpoint
For the main component L-alany-L-glutamine an acute dermal toxicity study indicated an LD50 >2000 mg/kg body weight and for the second main component potassium chloride acute dermal toxicity is not expected for intact skin from the nature of the molecule and its physicochemical properties.
Justification for classification or non-classification
Both individual main components (potassium chloride and L-alanyl-L-glutamine) showed LD50 values above 2000 mg/kg body weight for dermal (only data for L-alanyl-L-glutamine available, but potassium chloride is considered to be uncritical regarding its acute dermal toxicity in intact skin) and oral acute toxicity and therefore the substance "reaction mass of L-alanyl-L-glutamine and potassium chloride" does not have to be classified.
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