Registration Dossier
Registration Dossier
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EC number: 211-631-8 | CAS number: 676-83-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- fixed concentration procedure, steady stream air; saturated vapour 23.9 - 26.5 °C
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Methylphosphonous dichloride
- EC Number:
- 211-631-8
- EC Name:
- Methylphosphonous dichloride
- Cas Number:
- 676-83-5
- Molecular formula:
- CH3Cl2P
- IUPAC Name:
- dichloro(methyl)phosphane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- 1, 5, 7 or 10 minutes respectively
- No. of animals per sex per dose:
- male: 6 animals
female: 6 animals - Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- ca. 720 mg/L air
- Exp. duration:
- 1 min
- Remarks on result:
- other: concentration calculated
- Sex:
- female
- Dose descriptor:
- LC0
- Effect level:
- ca. 720 mg/L air
- Exp. duration:
- 1 min
- Remarks on result:
- other: concentration calculated
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- ca. 1 178 mg/L air
- Exp. duration:
- 5 min
- Remarks on result:
- other: concentration calculated
- Sex:
- male
- Dose descriptor:
- LC100
- Effect level:
- ca. 963 mg/L air
- Exp. duration:
- 10 min
- Remarks on result:
- other: concentration calculated
- Sex:
- female
- Dose descriptor:
- LC100
- Effect level:
- ca. 963 mg/L air
- Exp. duration:
- 10 min
- Remarks on result:
- other: concentration calculated
- Sex:
- female
- Dose descriptor:
- other: 4 of 6 animals died, within 1 - 2 day
- Effect level:
- ca. 1 178 mg/L air
- Exp. duration:
- 5 min
- Remarks on result:
- other: concentration calculated
- Sex:
- male
- Dose descriptor:
- other: 5 of 6 animals died within 2 days
- Effect level:
- 1 083 mg/L air
- Exp. duration:
- 7 min
- Remarks on result:
- other: concentration calculated
- Sex:
- female
- Dose descriptor:
- other: 5 of 6 animals died within 2 days
- Effect level:
- ca. 1 083 mg/L air
- Exp. duration:
- 7 min
- Remarks on result:
- other: concentration calculated
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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