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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
fixed concentration procedure, steady stream air; saturated vapour 23.9 - 26.5 °C
GLP compliance:
not specified
Test type:
fixed concentration procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Methylphosphonous dichloride
EC Number:
211-631-8
EC Name:
Methylphosphonous dichloride
Cas Number:
676-83-5
Molecular formula:
CH3Cl2P
IUPAC Name:
methylphosphonous dichloride

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
not specified
Remarks on duration:
1, 5, 7 or 10 minutes respectively
No. of animals per sex per dose:
male: 6 animals
female: 6 animals
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC0
Effect level:
ca. 720 mg/L air
Exp. duration:
1 min
Remarks on result:
other: concentration calculated
Sex:
female
Dose descriptor:
LC0
Effect level:
ca. 720 mg/L air
Exp. duration:
1 min
Remarks on result:
other: concentration calculated
Sex:
male
Dose descriptor:
LC0
Effect level:
ca. 1 178 mg/L air
Exp. duration:
5 min
Remarks on result:
other: concentration calculated
Sex:
male
Dose descriptor:
LC100
Effect level:
ca. 963 mg/L air
Exp. duration:
10 min
Remarks on result:
other: concentration calculated
Sex:
female
Dose descriptor:
LC100
Effect level:
ca. 963 mg/L air
Exp. duration:
10 min
Remarks on result:
other: concentration calculated
Sex:
female
Dose descriptor:
other: 4 of 6 animals died, within 1 - 2 day
Effect level:
ca. 1 178 mg/L air
Exp. duration:
5 min
Remarks on result:
other: concentration calculated
Sex:
male
Dose descriptor:
other: 5 of 6 animals died within 2 days
Effect level:
1 083 mg/L air
Exp. duration:
7 min
Remarks on result:
other: concentration calculated
Sex:
female
Dose descriptor:
other: 5 of 6 animals died within 2 days
Effect level:
ca. 1 083 mg/L air
Exp. duration:
7 min
Remarks on result:
other: concentration calculated

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU

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