Registration Dossier
Registration Dossier
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EC number: 271-230-9 | CAS number: 68526-82-9 The high boiling residuum from the distillation of C7-11 alcohols.
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline (405): GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction
- EC Number:
- 308-482-7
- EC Name:
- Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction
- Cas Number:
- 98072-31-2
- IUPAC Name:
- 98072-31-2
- Details on test material:
- - Name of test material (as cited in study report): MRD-85-608
- Physical state: liquid
- Analytical purity: assumed 100 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): neat (assumed 100%) - Duration of treatment / exposure:
- Single instillation
- Observation period (in vivo):
- Observations at 1, 4, 24, 48, and 72 hours post-instillation and once per day on days 4 and 7.
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- SCORING SYSTEM: Driaze
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0.83
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Effects were fully reversible within 4 days in all but one animal
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0.83
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Effects were fully reversible within 4 days in all but one animal
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0.5
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Effects were fully reversible within 4 days in all but one animal
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CAS# 98072-31-2 was found to be slightly irritating to the eyes. Effects were reversible within 4 days.
- Executive summary:
The ocular irritation potential of CAS# 98072-31-2 was evaluated following a single 0.1 ml instillation to the right eye of 6 rabbits. The treated eyes of all animals remained unwashed. Observations for signs of ocular irritation and toxicity were made at 1, 4, 24, 48, and 72 hours post-instillation and once per day on days 4 and 7. Ocular reactions were graded according to the Draize scale for scoring ocular lesions. Minimal irritation was observed in the animals; responses were limited to the conjunctiva and included redness, chemosis and discharge. All effects were fully reversible within 7 days post-instillation. In all but one animal, all effects were fully reversed within 4 days post-instillation.
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