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EC number: 271-230-9 | CAS number: 68526-82-9 The high boiling residuum from the distillation of C7-11 alcohols.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline (404): GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction
- EC Number:
- 308-482-7
- EC Name:
- Alkenes, C7-9, hydroformylation products, distn. residues, heavy cracked fraction
- Cas Number:
- 98072-31-2
- IUPAC Name:
- 98072-31-2
- Details on test material:
- - Name of test material (as cited in study report): MRD-85-608
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): assumed 100% (neat)
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 45 minutes, 24, 48, and 72 hours and on day 7 post-patch removal
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: back
- % coverage:
- Type of wrap if used: semi-occlusive
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 1.3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 1.5
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 1.5
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0.5
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0.6
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0.6
- Reversibility:
- not fully reversible within: 7 days
- Irritant / corrosive response data:
- Dermal exposure elicited very slight erythema in 4 animals and well-defined erythema in 2 animals at the 60 minute observation. Four animals displayed very slight edema at the 60 minute observation. Irritation increased slightly as the study progressed and at the 72 hour observation, two animals displayed well-defined erythema and one animal displayed moderate-to-severe erythema. Edema scores also increased and at the 72 hour observation two animals displayed very slight edema and one animal displayed slight edema. Irritation subsided slightly after the 72 hour observation and on day 7, two animals displayed very slight erythema and no edema, two animals displayed very slight erythema and very slight edema and one animal displayed well-defined erythema and very slight edema. Desquamation was noted in four of the six test animals at the day 7 observation period.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Slight irritation was noted, but subsided over a seven day observation period.
- Executive summary:
In this study, 6 rabbits were exposed to CAS# 98072-31-2 via a semi-occlusive dermal patch for 4 hours. Observations for skin irritation were made at 45 minutes, 24, 48, and 72 hours and on day 7 post-patch removal. Dermal exposure elicited very slight erythema in 4 animals and well-defined erythema in 2 animals at the 60 minute observation. Four animals displayed very slight edema at the 60 minute observation. Irritation increased slightly as the study progressed and at the 72 hour observation, two animals displayed well-defined erythema and one animal displayed moderate-to-severe erythema. Edema scores also increased and at the 72 hour observation two animals displayed very slight edema and one animal displayed slight edema. Irritation subsided slightly after the 72 hour observation and on day 7, two animals displayed very slight erythema and no edema, two animals displayed very slight erythema and very slight edema and one animal displayed well-defined erythema and very slight edema. Desquamation was noted in four of the six test animals at the day 7 observation period.
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