Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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EC number: 205-355-7 | CAS number: 139-13-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report, but basic information given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
- Principles of method if other than guideline:
- internal BASF guidelines
- GLP compliance:
- no
Test material
- Reference substance name:
- Trilon AS
- IUPAC Name:
- Trilon AS
- Reference substance name:
- Nitrilotriacetic acid
- EC Number:
- 205-355-7
- EC Name:
- Nitrilotriacetic acid
- Cas Number:
- 139-13-9
- Molecular formula:
- C6H9NO6
- IUPAC Name:
- 2-[bis(carboxymethyl)amino]acetic acid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: US rats
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 2, 16 and 30% aqueous suspension with traganth
- Details on oral exposure:
- Observation period: 14 days
- Doses:
- 200, 1600, 3200, 6400 mg/kg
- No. of animals per sex per dose:
- 20
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6 400 mg/kg bw
- Mortality:
- see table below
- Clinical signs:
- other: 3200 - 6400 mg/kg: immediately accelerated breathing, high-stepping gait, disturbed behaviour. 3 days thereafter no symptoms, then deterioration of health with crusty eyes and noses, intermittent breathing and with intensively ruffled fur. The animals wer
- Gross pathology:
- Sacrificed animals: no abnormalities detected.
Any other information on results incl. tables
| Dose (mg/kg) | Concentration (%) | No. of animals | Dead animals after | ||||
| 1 hour | 24 hours | 48 hours | 7 days | 14 days | |||
| 6400 | 30 | 20 | 0/20 | 0/20 | 0/20 | 3/20 | 4/20 |
| 3200 | 30 | 20 | 0/20 | 0/20 | 0/20 | 1/20 | 1/20 |
| 1600 | 16 | 20 | 0/20 | 0/20 | 0/20 | 0/20 | |
| 200 | 2 | 20 | 0/20 | 0/20 | 0/20 | 0/20 | |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
