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EC number: 939-616-8 | CAS number: 68391-03-7
- Life Cycle description
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- Endpoint summary
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- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Toxicological Summary
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- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Based on the available results from the read across studies, the test substance is considered to be corrosive to the skin and eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- From 23 February, 1988 to 8 March, 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- KL2 due to RA
- Justification for type of information:
- Refer to the Quaternary ammonium salts (QAS) category or section 13 of IUCLID for details on the category justification.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mohican Valley Rabbitry; Loudonville, Ohio
- Age at study initiation: Young adult
- Weight at study initiation: 2,736 to 3,450 g at study initiation
- Housing: Individual suspended wire-mesh cages. The animals were maintained in accordance with the recommendations contained in the "guide for care and use of laboratory animals" NIH publication, No. 85023.
- Diet: Purina Certified Rabbit Chow #5322
- Water: Tap water
- Acclimation period: 7 d
ENVIRONMENTAL CONDITIONS
- Temperature : 71-74 °F
- Humidity (%): 50-74%
- Photoperiod (hrs dark / hrs light): 12 h light/12 h dark
IN-LIFE DATES: From: 23 February, 1988 to 8 March, 1988 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mL/site
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 d
- Number of animals:
- 3 males and 3 females
- Details on study design:
- TEST SITE
0.5 mL dose was applied under secured 1 x 1 inch2 guaze patches that were overwrapped with a gauze binder secured with dermiform tape. Plastic restraint collars were applied and remained on the animals for the duration of the exposure period.
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: At the end of 4 h, the collars and bandages were removed and the sites wiped with wet disposable paper towels.
SCORING SYSTEM: Draize - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 5.6
- Max. score:
- 8
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: severely irritating (due to not completely reversible reactions (moderate irritation was still present in one rabbit); in addition desquamation was noted on all sites late in the study period and fissuring was present on two sites
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2.8
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 2.2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- ca. 2.6
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- ca. 3.6
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- ca. 1.6
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- ca. 3.6
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- ca. 2.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Average erythema score for all animals at 24h: 3; 48h: 3; 72h: 2.8
Average edema score for all animals at 24h: 3.2; 48h: 2.8; 72h: 2.2
Reversibility: Yes, the highest levels of irritation occurred two to three days after dosing and irritation subsequently decreased although moderate reactions still persisted in one animal after study Day 12.
The test substance induced moderate erythema and moderate to severe oedema on all sites. Irritation decreased as the study progressed, however, moderate irritation was present in one rabbit (score: erythema:2; edema:1) through study Day 11. - Other effects:
- Desquamation was noted on all sites late in the study period and fissuring was present on two sites.
- Interpretation of results:
- other: Category 1C (corrosive) based on CLP criteria
- Conclusions:
- Based on the results of the read across study, the test substance is considered to be corrosive.
- Executive summary:
A study was conducted to determine the skin irritation potential of the read across substance, Coco TMAC (33% active in water), in New Zealand White rabbits according to OECD 404 Guideline, in compliance with GLP. Six animals were treated with 0.5 mL undiluted read across substance (33%) in a semi-occlusive patch (1” X 1” gauze) that was overwrapped with a gauze binder and secured with dermiform tape. Plastic restraint collars were applied and remained on the animals for the duration of the 4 h exposure period, after which the tape and read across substance were removed. The Draize classification scoring criteria was used to evaluate the irritation potential. Application sites were observed for erythema and oedema at 4, 24, 48 and 72 h after exposure and then daily up to 14 d. The read across substance induced moderate erythema and moderate to severe edema on all sites. Remission of irritation signs occurred as the study progressed, however, moderate irritation was still present in one rabbit after study Day 12 (erythema: 2 ‘slight’; edema:1 ‘barely perceptible’). In addition, desquamation was noted on all sites late in the study period and fissuring was present on two sites. The Primary Irritation Index was calculated to be 5.6 (indicative of moderate irritation). Under the study conditions, due to persistence of irritation reactions in one animal as well as desquamation on all sites and fissuring on 2 sites, the read across substance is considered to be severely irritating. Under the study conditions, the read across substance (containing 33% a.i.) was found to be severely irritating to rabbit skin; therefore, 100% Coco TMAC can be considered to be corrosive (Naas, 1988). Based on the results of the read across, a similar corrosive potential is expected for the test substance.
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
- Reason / purpose for cross-reference:
- data waiving: supporting information
Referenceopen allclose all
Mortality: One rabbit was sacrificed in extremis on Day 3 due to broken back.
Body weight: No remarkable changes occurred.
Result details
Table 1: Table for skin irritation study |
||||
score (average animals investigated) |
time |
Erythema |
Edema |
|
average score |
< 1 hr After exposure |
2.6 |
1.5 |
|
24 h |
3 |
3.2 |
||
48 h |
3 |
2.8 |
||
72 h |
2.8 |
2.2 |
||
other times |
State time |
|
|
|
average score |
24h, 48h, 72h |
3.0 |
2.7 |
|
reversibility: * |
n.c |
n.c |
||
Average time for reversibility |
|
|
||
* c : completely reversible |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- From 22 February 1988 to 14 March, 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- KL2 due to RA
- Justification for type of information:
- Refer to the Quaternary ammonium salts (QAS) category or section 13 of IUCLID for details on the category justification.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Mohican Valley Rabbitry, Loudonville, Ohio
- Age at study initiation: Young adult
- Weight at study initiation: 2,634 to 3,104 g at study initiation
- Housing: Individual suspended wire-mesh cages. The animals were maintained in accordance with the recommendations contained in the "guide for care and use of laboratory animals" NIH publication, No. 8502
- Diet: Purina Certified Rabbit Chow #5322
- Water: Tap water
- Acclimation period: 7 d
ENVIRONMENTAL CONDITIONS
- Temperature : 67-74 °F
- Humidity (%): 40-74%
- Photoperiod (hrs dark / hrs light): 12 h/12 h
IN-LIFE DATES: From 23 February, 1988 to 8 March, 1988 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- Single treatment
- Observation period (in vivo):
- Both eyes were examined at approximately 1, 24, 48 and 72 h after dosing and at 96 h and 7, 14 and 21 d. In addition, both eyes of all rabbits were further examined at 72 h and 7, 14 and 21 d with sodium fluorescein and ultraviolet light.
- Number of animals or in vitro replicates:
- 5 males and 4 females
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Out of the 9 animals, the eye of the three rabbits were washed with 120 mL of lukewarm tap water for approximately 1 min.
- Time after start of exposure: 30 sec after dosing
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: Sodium fluorescein and ultraviolet light - Irritation parameter:
- other: Maximum average score (M.A.S)
- Basis:
- mean
- Time point:
- other: 14 d
- Score:
- 96.8
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 21 d
- Remarks on result:
- other: This value is for unwashed group
- Irritation parameter:
- other: Maximum average score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 69.7
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 21 d
- Remarks on result:
- other: This value is for washed group
- Irritation parameter:
- other: Maximum average score
- Basis:
- mean
- Time point:
- other: 96 h
- Score:
- 69.7
- Max. score:
- 110
- Reversibility:
- not fully reversible within: 21 d
- Remarks on result:
- other: This value is for washed group
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 1.03
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 2.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Remarks:
- (discharge)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 2.56
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 3.92
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 d
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- The test substance was maximally irritating for the unwashed group and extremely irritating for the washed group.
- Other effects:
- Purulent discharge, clear discharge, petite hemorrhage, blanching, corneal epithelial damage, corneal neovascularization, sodium fluorescein stain retention.
- Interpretation of results:
- other: Category 1 (irreversible effects on the eye) based on CLP criteria
- Conclusions:
- Based on the results of the read across study, the test substance is considered to cause irreversible effects on the eye.
- Executive summary:
A study was conducted to determine the skin irritation potential of the read across substance, Coco TMAC (33% active), in New Zealand White rabbits according to OECD 405 Guideline, in compliance with GLP. Nine rabbits received 0.1 mL of undiluted solution in one eye. The other eye remained untreated. The eyelids were held close for approximately 1 second after instillation. The eyes of three rabbits were washed for approximately 1 minute with 120 mL of lukewarm tap water commencing approximately 30 seconds after dosing. Both eyes were examined at for ocular irritation in accordance with the method of Draize approximately 1, 24, 48 and 72 h after dosing and at 96 h and 7, 14 and 21 d. In addition, both eyes of all rabbits were further examined at 72 h and 7, 14 and 21 d with sodium fluorescein and ultraviolet light. Body weights were obtained and recorded on study day 0 (initiation) and at termination (Day 21). Based on the data obtained, the Maximum Average Scores (according to Kay and Calandra) for the read across substance were calculated to be 96.8 (extremely irritating) at 14 d for the unwashed group and 69.7 (severely irritating) at both 72 and 96 h for the washed group. Purulent discharge, clear discharge, petite haemorrhage, blanching, corneal epithelial damage and peeling, corneal neovascularisation, Sodium fluoresceinstain retention, and vascularised granulation scar tissue was observed in all 6 animals. Same effects were observed in the washed group, except for vascularised granulation scar tissue. There were no deaths or remarkable body weight changes during the study period. Under the study conditions, the read across substance is considered to cause irreversible effects on the eye (Naas, 1988). Based on the results of the read across study, a similar corrosive potential can be expected for the test substance.
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro eye irritation study does not need to be conducted because adequate data from an in vivo eye irritation study are available
- Reason / purpose for cross-reference:
- data waiving: supporting information
Referenceopen allclose all
Table 1. Results of eye irritation study
|
||||
|
Cornea |
Iris |
Conjunctiva |
|
redness |
chemosis |
|||
Score (average of animals investigated) |
0 to 4 |
0 to 2 |
0 to 3 |
0 to4 |
60 min |
3.0 |
1 |
1 |
4 |
24 h |
2.8 |
1 |
1.7 |
4 |
48 h |
2.8 |
1 |
2.3 |
4 |
72 h |
2.8 |
1 |
2.8 |
4 |
21 days |
4 |
0.3 |
1.8 |
2.5 |
Average 24h, 48h, 72h |
2.8 |
1 |
2.3 |
4 |
Area effected |
> 75% |
|||
Maximum average score (including area affected, max 110) |
96.8 on day 14 |
|||
Reversibility* |
n |
|||
Average time for reversion |
|
|||
Give method of calculation maximum average score. * c : completely reversible |
Cornea: (opacity * area) * 5 Max. score: 80 + 10 + 20 = 110 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin
A study was conducted to determine the skin irritation potential of the read across substance, Coco TMAC (33% active in water), in New Zealand White rabbits according to OECD 404 Guideline, in compliance with GLP. Six animals were treated with 0.5 mL undiluted read across substance (33%) in a semi-occlusive patch (1” X 1” gauze) that was overwrapped with a gauze binder and secured with dermiform tape. Plastic restraint collars were applied and remained on the animals for the duration of the 4 h exposure period, after which the tape and read across substance were removed. The Draize classification scoring criteria was used to evaluate the irritation potential. Application sites were observed for erythema and oedema at 4, 24, 48 and 72 h after exposure and then daily up to 14 d. The read across substance induced moderate erythema and moderate to severe edema on all sites. Remission of irritation signs occurred as the study progressed, however, moderate irritation was still present in one rabbit after study Day 12 (erythema: 2 ‘slight’; edema:1 ‘barely perceptible’). In addition, desquamation was noted on all sites late in the study period and fissuring was present on two sites. The Primary Irritation Index was calculated to be 5.6 (indicative of moderate irritation). Under the study conditions, due to persistence of irritation reactions in one animal as well as desquamation on all sites and fissuring on 2 sites, the read across substance is considered to be severely irritating. Under the study conditions, the read across substance (containing 33% a.i.) was found to be severely irritating to rabbit skin; therefore, 100% Coco TMAC can be considered to be corrosive (Naas, 1988). Based on the results of the read across, a similar corrosive potential is expected for the test substance.
Eye
A study was conducted to determine the skin irritation potential of the read across substance, Coco TMAC (33% active), in New Zealand White rabbits according to OECD 405 Guideline, in compliance with GLP. Nine rabbits received 0.1 mL of undiluted solution in one eye. The other eye remained untreated. The eyelids were held close for approximately 1 second after instillation. The eyes of three rabbits were washed for approximately 1 minute with 120 mL of lukewarm tap water commencing approximately 30 seconds after dosing. Both eyes were examined at for ocular irritation in accordance with the method of Draize approximately 1, 24, 48 and 72 h after dosing and at 96 h and 7, 14 and 21 d. In addition, both eyes of all rabbits were further examined at 72 h and 7, 14 and 21 d with sodium fluorescein and ultraviolet light. Body weights were obtained and recorded on study day 0 (initiation) and at termination (Day 21). Based on the data obtained, the Maximum Average Scores (according to Kay and Calandra) for the read across substance were calculated to be 96.8 (extremely irritating) at 14 d for the unwashed group and 69.7 (severely irritating) at both 72 and 96 h for the washed group. Purulent discharge, clear discharge, petite haemorrhage, blanching, corneal epithelial damage and peeling, corneal neovascularisation, Sodium fluoresceinstain retention, and vascularised granulation scar tissue was observed in all 6 animals. Same effects were observed in the washed group, except for vascularised granulation scar tissue. There were no deaths or remarkable body weight changes during the study period. Under the study conditions, the read across substance is considered to cause irreversible effects on the eye (Naas, 1988). Based on the results of the read across study, a similar corrosive potential can be expected for the test substance.
The biocide assessment report available from RMS Italy on Coco TMAC also concluded that: “according to the studies presented by both applicants, coco alkyltrimethylammonium chloride is corrosive for the skin and it is also severely irritant to the eyes” (ECHA biocides assessment report, 2016).
Therefore, based on the available information on the read across substance and in line with the biocides assessment report, the test substance is considered to be corrosive to both skin and eyes.
Justification for classification or non-classification
Based on the results of the read across in vivo skin and eye irritation studies, the undiluted test substance warrants a corrosive, ‘Skin Corr. 1C; H314: Causes severe skin burns and eye damage’ as well as serious eye damage, ‘Eye dam. 1; H31: Causes serious eye damage’ classification according to the EU CLP criteria (Regulation EC 1272/2008). Labelling for this endpoint is covered by the above classifications for skin effects.
With regard to respiratory tract irritation, although C12-18 TMAC is a very corrosive substance, its low vapour pressure prohibits the occurrence of respiratory irritation by vapour. Further, the classification of corrosive is already considered to implicitly cover the potential of RTI; therefore an additional Cat.3 is considered to be superfluous (Guidance CLP Ch. 3.8.2.5).
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