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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study is scientifically acceptable.

Data source

Reference
Reference Type:
publication
Title:
Toxicological Study of Potassium Bromate. I. Absorption, Metabolism and Excretion of Potassium Bromate after oral Administration in Rats
Author:
Kawana, K.; Nakaoka, T.; Horiguchi, Y.; Watanabe, S.; Watanabe, S.; Kawauchi, S.
Year:
1991
Bibliographic source:
Eisei Kaguku 1991, 37, (4), 258-265.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
other:
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium bromate
EC Number:
231-829-8
EC Name:
Potassium bromate
Cas Number:
7758-01-2
Molecular formula:
BrHO3.K
IUPAC Name:
potassium bromate
Details on test material:
please see publication for further details

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
please see publication for further details

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Details on oral exposure:
please see publication for further details
Doses:
85, 159, 177, 325, 337, 602 mg/kg body weight
No. of animals per sex per dose:
85 mg/kg: 5 m
159 mg/kg: 5 m
177 mg/kg: 5 f
325 mg/kg: 5 m
337 mg/kg: 5 f
602 mg/kg: 5 m
Control animals:
no
Details on study design:
see publication for further details
Statistics:
see publication for further details

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
157 mg/kg bw
Based on:
test mat.
Mortality:
please see publication for further details
Clinical signs:
other: please see publication for further details
Gross pathology:
please see publication for further details
Other findings:
please see publication for further details

Applicant's summary and conclusion

Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008
Conclusions:
Based on the results, this substance is classified at "Toxic" by oral ingestion, according to CLP.
Executive summary:

The substances was tested equivalent to the OECD 401 method to assess the acute oral toxicity of the material in male and female rats (5 of each sex). Based on results of exposure of the substance the LD50of the substance has been determined to be 157 mg/kg bodyweight in rats.