Registration Dossier
Registration Dossier
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EC number: 405-400-2 | CAS number: 54253-62-2 KUPFER-II-METHANSULFONAT; KUPFERMETHANSULFONAT
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study conducted by GLP accredited lab according to recognised guideline method. Data provided by ECHA from migrated NONS file. Litle detail available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Copper(II) methanesulfonate
- EC Number:
- 405-400-2
- EC Name:
- Copper(II) methanesulfonate
- Cas Number:
- 54253-62-2
- Molecular formula:
- C2H6CuO6S2
- IUPAC Name:
- copper(2+) dimethanesulfonate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- 0.1 ml (0.85g)
- Observation period (in vivo):
- 10 days
- Number of animals or in vitro replicates:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
Any other information on results incl. tables
In the course of the test opalescent corneal opticity, iridial inflammation and conjunctival irritation increased. The severe ocular reactions persisted, therefore the animal was killed on day 10.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance was classified as severe eye irritant (R41), while according to CLP it should be classified as Eye Dam. 1
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