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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
developmental toxicity
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 371-40-4
Author:
Danish EPA Model
Year:
2012
Bibliographic source:
QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:Commercial

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Modelling database
Principles of method if other than guideline:
Teratogenicity (FDA TERIS), human: Multicase model A49
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-fluoroaniline
EC Number:
206-735-5
EC Name:
4-fluoroaniline
Cas Number:
371-40-4
Molecular formula:
C6H6FN
IUPAC Name:
4-fluoroaniline
Details on test material:
- Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
other: human
Strain:
other: Not applicable

Administration / exposure

Route of administration:
other:
Type of inhalation exposure (if applicable):
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Details on mating procedure:
no data
Duration of treatment / exposure:
no data
Frequency of treatment:
no data
Duration of test:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
no data
Basis:

No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Results (fetuses)

Details on embryotoxic / teratogenic effects:
Embryotoxic / teratogenic effects:no effects

Effect levels (fetuses)

Based on:
test mat.
Basis for effect level:
other: teratogenicity

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
4-fluoroaniline gives negative results in a Unscheduled DNA synthesis test conducted in Rat hepatocytes
Executive summary:

4-fluoroaniline gives negative results in a Unscheduled DNA synthesis test conducted in Rat hepatocytes