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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to birds

Currently viewing:

Administrative data

Endpoint:
short-term toxicity to birds: acute oral toxicity test
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
DPIM: FFY000
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials):- Toxicology and Applied Pharmacology. 21 (1972), 315.
Reference Type:
review article or handbook
Title:
RTECS Number: BY1575000
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972
Reference Type:
review article or handbook
Title:
DOSE No.: F60
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE):- Schafer, E. W. Toxicol. Appl. Pharmacol. 1972, 21, 315-330.
Reference Type:
other: Authoritative data base
Title:
GCID: 221820
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource):- Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is taken from SAX, DOSE, RTECS and ACToR Database
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-fluoroaniline
EC Number:
206-735-5
EC Name:
4-fluoroaniline
Cas Number:
371-40-4
Molecular formula:
C6H6FN
IUPAC Name:
4-fluoroaniline
Details on test material:
- Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid
Dose method:
other: peroral
Analytical monitoring:
not specified
Vehicle:
not specified

Test organisms

Test organisms (species):
other: Redwing blackbird

Study design

Remarks:
Exposure duration not reported
No. of animals per sex per dose and/or stage:
no data
Control animals:
not specified

Results and discussion

Effect levels
Dose descriptor:
other: LD50
Effect level:
100 mg/kg bw
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Exposure duration not reported
Repellency factors (if applicable):
Details of toxic effects not reported other than lethal dose value

Applicant's summary and conclusion

Conclusions:
Oral toxicity (LD50) of 4-fluoroaniline to Redwing blackbird was examined at dose concentration of 100 mg/kg of body weight.
Executive summary:

The acute oral toxicity of 369 chemicals was determined for 1 or more species of wild birds, always including either red-winged blackbirds or starlings. Of these, 180 chemicals were toxic to 1 or more species at 100 mg/kg or less. Statistical comparison of redwing, starling and rat data indicated that redwings were more sensitive to chemicals than starlings, and both were more sensitive than rats.

Oral toxicity (LD50) of 4-fluoroaniline to Redwing blackbird was examined at dose concentration of 100 mg/kg of body weight.