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Registration Dossier
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EC number: 206-735-5 | CAS number: 371-40-4
Toxicity to birds
Administrative data
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- DPIM: FFY000
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials):- Toxicology and Applied Pharmacology. 21 (1972), 315.
- Reference Type:
- review article or handbook
- Title:
- RTECS Number: BY1575000
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances):- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972
- Reference Type:
- review article or handbook
- Title:
- DOSE No.: F60
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE):- Schafer, E. W. Toxicol. Appl. Pharmacol. 1972, 21, 315-330.
- Reference Type:
- other: Authoritative data base
- Title:
- GCID: 221820
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource):- Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is taken from SAX, DOSE, RTECS and ACToR Database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-fluoroaniline
- EC Number:
- 206-735-5
- EC Name:
- 4-fluoroaniline
- Cas Number:
- 371-40-4
- Molecular formula:
- C6H6FN
- IUPAC Name:
- 4-fluoroaniline
- Details on test material:
- - Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Dose method:
- other: peroral
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- other: Redwing blackbird
Study design
- Remarks:
- Exposure duration not reported
- No. of animals per sex per dose and/or stage:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- other: LD50
- Effect level:
- 100 mg/kg bw
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Exposure duration not reported
- Repellency factors (if applicable):
- Details of toxic effects not reported other than lethal dose value
Applicant's summary and conclusion
- Conclusions:
- Oral toxicity (LD50) of 4-fluoroaniline to Redwing blackbird was examined at dose concentration of 100 mg/kg of body weight.
- Executive summary:
The acute oral toxicity of 369 chemicals was determined for 1 or more species of wild birds, always including either red-winged blackbirds or starlings. Of these, 180 chemicals were toxic to 1 or more species at 100 mg/kg or less. Statistical comparison of redwing, starling and rat data indicated that redwings were more sensitive to chemicals than starlings, and both were more sensitive than rats.
Oral toxicity (LD50) of 4-fluoroaniline to Redwing blackbird was examined at dose concentration of 100 mg/kg of body weight.
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