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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
chronic toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS Number : DO8925000
Author:
Woodart et al.
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):Woodart et al.,Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,26,1948

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS Database
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methoxybenzyl alcohol
EC Number:
203-273-6
EC Name:
4-methoxybenzyl alcohol
Cas Number:
105-13-5
Molecular formula:
C8-H10-O2
IUPAC Name:
(4-methoxyphenyl)methanol
Test material form:
liquid
Details on test material:
- Name of test material: 4-methoxybenzyl alcohol
- IUIPAC name: 4-methoxybenzyl alcohol
- Molecular Formula: C8H10O2
- Molecular Weight: 138.166 g/mol
- Substance type: Organic
- Physical state: Liquid
- Purity: 99.9%

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
13 weeks
Frequency of treatment:
intermittent
Doses / concentrations
Remarks:
0.06mg/Kg
Control animals:
not specified

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
ehavioral - somnolence (general depressed activity) was observed.
Dermal irritation:
effects observed, treatment-related
Description (incidence and severity):
Yes ,Dermal irritation was moderatley observed on abrraded skin by repeated application.
Mortality:
not specified
Gross pathological findings:
no effects observed
Description (incidence and severity):
No Leasion was observed in survived animals.
Details on results:
OTHER FINDINGS : Toxic Effects : B
Related to Chronic Data - death

Effect levels

Key result
Dose descriptor:
LOAEL
Effect level:
0.06 mg/kg bw/day
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: overall effects : Toxic Effects : Behavioral - somnolence (general depressed activity) Related to Chronic Data - death
Remarks on result:
other: Low adverse effects were observed

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The chronic toxicity study for test substance was tested in rabbit by dermal exposure of 0.06mg/Kg of substance for 13 weeks. The LOAEL was considered to be 0.06mg/Kg in rabbits by dermal exposure.
Executive summary:

The test substance was evaluated for its repeated dose dermal toxicity study in rabbits for 13 weeks. The test material was exposed to abraded skin of rabbits in the concentration of 0.06mg/Kg for 13 weeks. The animals were observed for clinical sign, mortality, gross and histopathology. Dermal irritation was observed in animals. Somnolence (general depressed activity) was also observed. Therefore LOAEL was considered to be 0.06mg/Kg in rabbits for 13 weeks by dermal exposure. As it is a single dose study and no significant effect were observed. The test substance cannot be classified as per CLP for repeated dose toxicity.