Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 928-253-0 | CAS number: 1174918-40-1
Endpoint summary
Administrative data
Description of key information
Skin sensitisation
C10-12 isoalkanes (<2% aromatics), C11-C14 n-alkanes (<2% aromatics) and C10-C13 (<2% aromatics) were not dermal sensitizers using a Magnusson and Kligman Guinea-Pig Maximization test (OECD TG 406).
Respiratory sensitisation
No data
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In Magnusson and Kligman Guinea-Pig Maximization test (OECD TG 406), C10-12 isoalkanes (<2% aromatics), C11-C14 n-alkanes (<2% aromatics) and C10-C13 (<2% aromatics) were not dermal sensitizers using a Magnusson and Kligman Guinea-Pig Maximization test (OECD TG 406). Moreover, in studies on human volunteers using C14-C20 aliphatics (<2% aromatics), there were no signs of irritation or sensitization effects of the test substances (IUCLID section 7.10.4).
Respiratory sensitisation
Endpoint conclusion
- Additional information:
There are no reports of respiratory sensitization from C14-20 aliphatics (<2 % aromatics) in laboratory animals or humans. However, skin sensitization studies utilizing C9-14 aliphatics (<2 % aromatics) found no indication of skin sensitization in guinea pigs. Additional studies on C14-C20 aliphatics (<2% aromatics) in humans also found no indication of skin sensitization. With these observations, it is presumed that C14-20 aliphatics (<2% aromatics) will not be a respiratory sensitizing agents.
Justification for classification or non-classification
These findings do not warrant the classification of C14-20 aliphatics (<2 % aromatics) hydrocarbon solvents as a skin or respiratory sensitizer under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
