Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 6 March to 20 September 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: According to the OECD Guideline and it is GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Physical state: clear colorless liquid
- Storage condition of test material: room temperature in the dark

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
3.47

Any other information on results incl. tables

 Injection Retention Time (mins) Capacity Factor (k')  Log k'  Log Pow 
6.717  3.235  0.510  3.47 
6.721  3.238  0.510   3.47

Mean Log Pow: 3.47

Partittion coefficient 2.96 x10^3

Applicant's summary and conclusion

Conclusions:
The partition coefficient of the test item has been determined to be log Pow 3.47.
Executive summary:

Log Pow 3.47, using the HPLC method, designed to be compatible with Method a8 Partition Coefficient of Commission Regulation and Method 117 of the OECD Guidelines.