2-(2-phenoxyethoxy)ethanol

Toxicity to reproduction: other studies

Administrative data

Endpoint:

toxicity to reproduction: other studies

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment.

Data source

Reference

Reference Type:

publication

Title:

Experimental studies on toxicity of ethylene glycol ethers in Japan

Author:

Nagano, K. et al.

Year:

1984

Bibliographic source:

Environ Health Perspect 57:75-84

Materials and methods

Principles of method if other than guideline:

Evaluation of the toxicity of ethylene glycol alkyl ethers to the testis of mice.

GLP compliance:

not specified

Type of method:

in vivo

Test material

Test material information

Constituent 1

Reference substance name:

2-phenoxyethanol

EC Number:

204-589-7

EC Name:

2-phenoxyethanol

Cas Number:

122-99-6

Molecular formula:

C8H10O2

IUPAC Name:

2-phenoxyethanol

Details on test material:

- Name of test material (as cited in study report): Ethylene glycol monophenyl ether
- Analytical purity: no data
- Other: Source: Wako Chemical Co.

Test animals

Species:

mouse

Strain:

ICL-ICR

Sex:

male

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: The authors mention water and olive oil as vehicles, without specifying which vehicle was actually used for the test substance.

Analytical verification of doses or concentrations:

no

Duration of treatment / exposure:

5 weeks

Frequency of treatment:

5 days per week

Duration of test:

5 weeks

Doses / concentrations

Remarks:

Doses / Concentrations:
500, 1000 mg/kg bw
Basis:
nominal conc.

No. of animals per sex per dose:

5

Control animals:

yes

Results and discussion

Effect levels

Dose descriptor:

NOEL

Effect level:

1 000 mg/kg bw/day (nominal)

Sex:

male

Basis for effect level:

other: weight of the testis

Observed effects

There was no effect of treatment on weights of testes or combined weights of the seminal vesicles and coagulating gland. Whether the test material had any effects on the morphology of blood or the testes was not stated.

Any other information on results incl. tables

Ethylene glycol monomethyl and ethyl ethers and acetates and ethylene glycol dimethyl ether were tested in this study and were found to produce decreased testicular weights and leukocyte counts and dose-related atrophy of the seminiferous tubule epithelium.