diethyl 1,4-cyclohexanedicarboxylate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23rd December 1994 to 31st March 1995

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of relevant results.

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Date of inspection: 31st January 1994 Date of signature: 16th March 1994

Type of method:

flask method

Specific details on test material used for the study:

Container: metal canister
Storage conditions: Room temperature until 1st December 1994, thereafter room temperature in the dark.

Key result

Water solubility:

1.28 g/L

Incubation duration:

25 - 73 h

Temp.:

20 °C

pH:

6.8 - 7.1

Individual results:

Equilibration time at 30°C (hours)	Concentration (g/L)	pH
25^1/2	1.26	7.1
49^1/2	1.31	6.9
73^1/2	1.27	6.8

Repeatability is less than 15%; therefore results are considered constant (i.e. equilibrium reached), and the retained value is the mean of the three individual results.

Conclusions:

Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The water solubility of ST 02 C 94 was determined to be 1.28 g/L of solution at a temperature of 20.0°C and pH 7.

Executive summary:

Method: The experimental procedure used complied with that specified in EU Method A6, flask method.

Comments: The absorbance of the pair of standards associated with a particular sample were corrected to nominal concentration and the mean value taken prior to the calculation of the sample concentration.

Results: The water solubility of ST 02 C 94 was determined to be 1.28 g/L of solution at a temperature of 20 +/- 0.5°C and pH 6.8 -7.1.

Description of key information

Experimental water solubility at 20°C and pH 7.
Considered as soluble, with equilibrium reached from =< 24h. 

Key value for chemical safety assessment

Water solubility:

1.28 g/L

at the temperature of:

20 °C

Additional information

An experimental study on water solubility measurement of the test material, was conducted under GLP, and considered as fully reliable. Therefore the result is considered as key data.