Pentafluoroiodoethane

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1973

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: The report is only a rough summary. Duration of exposure 2 hours instead of 4 hours. No analytical data for dose concentrations mentioned. No individual data shown. Study was conducted prior to GLP implementation.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

no guideline followed

GLP compliance:

no

Remarks:

Study was performed prior to implementation of GLP

Test type:

other: acute inhalation, no Guideline mentioned

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Pentafluorjodaethan

IUPAC Name:

Pentafluorjodaethan

Constituent 2

Reference substance name:

Pentafluoroiodoethane

EC Number:

206-566-7

EC Name:

Pentafluoroiodoethane

Cas Number:

354-64-3

Molecular formula:

C2F5I

IUPAC Name:

1,1,1,2,2-pentafluoro-2-iodoethane

Details on test material:

Chemical pure gas
Concentration: 99.8%
Residual: C2F4 0.2%
Density: 2.2 g/cm3

Test animals

Species:

other: rat and guinea pigs

Strain:

not specified

Sex:

female

Details on test animals or test system and environmental conditions:

RATS:
- Source: SPF Wistar rats from company breading
Weight at study start: 92 - 112 g
GUINEA PIGS:
- Source: n.a.
Weight at study start: 212 - 290 g

- Age at study initiation: n.a.
- Fasting period before study: no
- Housing:
- Diet (e.g. ad libitum): ALTROMIN R (diet for rats) and ALTROMIN MS (diet for guinea pigs)
- Water (e.g. ad libitum): yes
- Acclimation period: n.a.
-Makrolon cages with wood shavings

ENVIRONMENTAL CONDITIONS
- Temperature in room (°C): 21.4°C to 22.7°C
- Humidity (%): n.a.
Atmospheric pressure: 752 - 769 mm/Hg
- Air changes (per hr): mechanical, but no value mentioned
- Photoperiod (hrs dark / hrs light): n.a.

Administration / exposure

Route of administration:

inhalation: gas

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: closed apparatus (acc. to Dr. J. Scholz, Medizin und Chemie, Band VI, page 189 - 192)
- Exposure chamber volume: n.a.
- Method of holding animals in test chamber: n.a.
- Source and rate of air: n.a.

- Treatment of exhaust air: exhaust CO2 was absorbed in an alkali cartridge
- consumed oxigene was repaced by fresh oxigene via a gas-burette
- Temperature in closed apparature during exposure (°C): 22°C to 24°C
- humidity, pressure in air chamber: n.a.

TEST ATMOSPHERE
- Brief description of analytical method used: n.a.
- Samples taken from breathing zone: n.a., but the oxigen consumption was measured throughout the exposure phase.

VEHICLE
- Composition of vehicle (if applicable): air
- Justification of choice of vehicle: n.a.

TEST ATMOSPHERE (if not tabulated): concentration of Pentafluorjodaethan as mentioned mixed with normal air.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

ca. 2 h

Concentrations:

Rat:
5 vol %, 7.5 vol% and 10 vol %
Guinea pig:
10 vol %, 15 vol % and 20 vol %

No. of animals per sex per dose:

Rat: 4 females/ dose
Guinea pig: 2 females/ dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs,

Results and discussion

Effect levels

Effect levels 1

Sex:

female

Dose descriptor:

other: LC50 (rat)

Effect level:

> 7.5 - <= 10 other: vol %

Based on:

test mat.

Exp. duration:

120 min

Effect levels 2

Sex:

female

Dose descriptor:

other: LC50 (Guinea pig)

Effect level:

> 15 - <= 20 other: vol %

Based on:

test mat.

Exp. duration:

120 min

Mortality:

Rats: All animals of the 10 vol % dose group died within 78 to 110 minutes after start of exposure..
Guinea Pig: All animals of the 20 vol % dose group died within 76 to 80 Minutes after start of exposure

Clinical signs:

other: Rats: at 5 vol %: 1 min after start of exposure agitated. 5 min after start of exposure accelerated breathing and imbalanced behavior. 15 min. after start of exposure face down position, trying to run, no reflexes when acustic stimulus appeared. 5 minute

Body weight:

n.a.

Gross pathology:

n.a.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

In conclusion after 120 minutes of inhalation the LC50 rat is greater 7.5 vol % and less or similar to 10 Vol % and the LC50 guinea pig is greater 10 vol % and less or similar to 20 Vol %.

Executive summary:

Four female rats and two Guinea pigs per dosing group were exposed to Pentafluorjodaethan gas (99.8 %) by inhalation for 2 hours.

Rats were dosed at 5, 7.5 and 10 vol %, whereas the guinea pigs were dosed at 10, 15 and 20 vol %. Thereafter, the survivors were observed for a period of 14 day.

All four rats of the 10 vol % dose group died within the exposure period. Rats of the lower dose groups survived the exposure.

The two guinea pigs of the 20 vol % dose group died within the exposure period. Animals of the lower exposure groups survived the exposure.

In conclusion after 120 minutes of inhalation the Pentafluorjodeathan the LC50 rat is greater 7.5 vol % and less to 10 Vol % and the LC50 guinea pig is greater 10 vol % and less to 20 Vol %.