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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1973
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The report is only a rough summary. Duration of exposure 2 hours instead of 4 hours. No analytical data for dose concentrations mentioned. No individual data shown. Study was conducted prior to GLP implementation.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Remarks:
Study was performed prior to implementation of GLP
Test type:
other: acute inhalation, no Guideline mentioned
Limit test:
no

Test material

Constituent 1
Reference substance name:
Pentafluorjodaethan
IUPAC Name:
Pentafluorjodaethan
Constituent 2
Chemical structure
Reference substance name:
Pentafluoroiodoethane
EC Number:
206-566-7
EC Name:
Pentafluoroiodoethane
Cas Number:
354-64-3
Molecular formula:
C2F5I
IUPAC Name:
pentafluoroiodoethane
Details on test material:
Chemical pure gas
Concentration: 99.8%
Residual: C2F4 0.2%
Density: 2.2 g/cm3

Test animals

Species:
other: rat and guinea pigs
Strain:
not specified
Sex:
female
Details on test animals or test system and environmental conditions:
RATS:
- Source: SPF Wistar rats from company breading
Weight at study start: 92 - 112 g
GUINEA PIGS:
- Source: n.a.
Weight at study start: 212 - 290 g

- Age at study initiation: n.a.
- Fasting period before study: no
- Housing:
- Diet (e.g. ad libitum): ALTROMIN R (diet for rats) and ALTROMIN MS (diet for guinea pigs)
- Water (e.g. ad libitum): yes
- Acclimation period: n.a.
-Makrolon cages with wood shavings

ENVIRONMENTAL CONDITIONS
- Temperature in room (°C): 21.4°C to 22.7°C
- Humidity (%): n.a.
Atmospheric pressure: 752 - 769 mm/Hg
- Air changes (per hr): mechanical, but no value mentioned
- Photoperiod (hrs dark / hrs light): n.a.

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: closed apparatus (acc. to Dr. J. Scholz, Medizin und Chemie, Band VI, page 189 - 192)
- Exposure chamber volume: n.a.
- Method of holding animals in test chamber: n.a.
- Source and rate of air: n.a.

- Treatment of exhaust air: exhaust CO2 was absorbed in an alkali cartridge
- consumed oxigene was repaced by fresh oxigene via a gas-burette
- Temperature in closed apparature during exposure (°C): 22°C to 24°C
- humidity, pressure in air chamber: n.a.

TEST ATMOSPHERE
- Brief description of analytical method used: n.a.
- Samples taken from breathing zone: n.a., but the oxigen consumption was measured throughout the exposure phase.

VEHICLE
- Composition of vehicle (if applicable): air
- Justification of choice of vehicle: n.a.

TEST ATMOSPHERE (if not tabulated): concentration of Pentafluorjodaethan as mentioned mixed with normal air.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 2 h
Concentrations:
Rat:
5 vol %, 7.5 vol% and 10 vol %
Guinea pig:
10 vol %, 15 vol % and 20 vol %
No. of animals per sex per dose:
Rat: 4 females/ dose
Guinea pig: 2 females/ dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs,

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
other: LC50 (rat)
Effect level:
> 7.5 - <= 10 other: vol %
Based on:
test mat.
Exp. duration:
120 min
Sex:
female
Dose descriptor:
other: LC50 (Guinea pig)
Effect level:
> 15 - <= 20 other: vol %
Based on:
test mat.
Exp. duration:
120 min
Mortality:
Rats: All animals of the 10 vol % dose group died within 78 to 110 minutes after start of exposure..
Guinea Pig: All animals of the 20 vol % dose group died within 76 to 80 Minutes after start of exposure
Clinical signs:
other: Rats: at 5 vol %: 1 min after start of exposure agitated. 5 min after start of exposure accelerated breathing and imbalanced behavior. 15 min. after start of exposure face down position, trying to run, no reflexes when acustic stimulus appeared. 5 minute
Body weight:
n.a.
Gross pathology:
n.a.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
In conclusion after 120 minutes of inhalation the LC50 rat is greater 7.5 vol % and less or similar to 10 Vol % and the LC50 guinea pig is greater 10 vol % and less or similar to 20 Vol %.
Executive summary:

Four female rats and two Guinea pigs per dosing group were exposed to Pentafluorjodaethan gas (99.8 %) by inhalation for 2 hours.

Rats were dosed at 5, 7.5 and 10 vol %, whereas the guinea pigs were dosed at 10, 15 and 20 vol %. Thereafter, the survivors were observed for a period of 14 day.

All four rats of the 10 vol % dose group died within the exposure period. Rats of the lower dose groups survived the exposure.

The two guinea pigs of the 20 vol % dose group died within the exposure period. Animals of the lower exposure groups survived the exposure.

In conclusion after 120 minutes of inhalation the Pentafluorjodeathan the LC50 rat is greater 7.5 vol % and less to 10 Vol % and the LC50 guinea pig is greater 10 vol % and less to 20 Vol %.