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EC number: 252-772-5
CAS number: 35869-64-8
on the integrated testing strategy [ECHA R.7c, 2008] a stepwise approach
to hazard identification on terrestrial organisms is required. Tests of
toxicity on earthworm were considered as first step, due to the fact
that earthworms are exposed via multiple uptake routes (soil pore water,
ingestion of soil material, soil air, secondary poisoning).
the 'red disazo condensation pigments’ two acute toxicity tests on
(CAS 68516-75-6 and CAS 71566-54-6) were performed. In this tests no
acute effects on earthworms occurred after 14 days exposure to 1000
mg/kg soil dw. This confirms the results from the aquatic tests where no
hazard was identified.
can be expected that ‘red disazo condensation pigments’ are essentially
not bioavailable, due to the large molecular size together with the
negligible low solubility. Therefore it can be assumed with sufficient
confidence, that further tests on terrestrial organisms would not
provide any additional information for improving the risk assessment.
Hence tests on plants and terrestrial microorganisms are not required.
the molecular structure and the physico-chemical properties of the ‘red
disazo condensation pigments’ are quite similar, the available studies
are sufficient to cover the terrestrial toxicity endpoints. This read
across approach is in accordance with Regulation (EC) No 1907/2006,
Annex XI, 1.5. Grouping of substance and read across approach as it is
explained within the analogue justification in Annex I.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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