Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication but only limited data is given. (Concentration of vapour in saturated atmosphere is not given, no data on clinical signs and observations, no necropsy performed, no details on test material given.)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1969

Materials and methods

Principles of method if other than guideline:
Method: according to Smyth, Carpenter, Weil, Pozzani and Striegel: Range-Finding Toxicity Data: List VI, Amer. Ind. Hyg. Assoc. J. 23: 95 (1962) for details see any other information on materials and methods
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[2-(3-aminopropoxy)ethoxy]ethanol
EC Number:
203-960-0
EC Name:
2-[2-(3-aminopropoxy)ethoxy]ethanol
Cas Number:
112-33-4
Molecular formula:
C7H17NO3
IUPAC Name:
2-[2-(3-aminopropoxy)ethoxy]ethanol
Details on test material:
- Name of test material (as cited in study report): 3-Aminopropoxy-2-ethoxy ethanol

Test animals

Species:
rat
Strain:
other: albino
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: rats are exposed to a flowing stream of vapour-ladened air
- Method of conditioning air: The vapour-air mixture is generated by passing 2.5 L/min of dried air at room temperature through a fritted glass disc immersed to a depth of at least one inch in approximately 50 mL of the test chemical contained in a gas-washing bottle.

TEST ATMOSPHERE
- Samples taken from breathing zone: no data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Concentrations:
no data
No. of animals per sex per dose:
6 males or females
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not given
- Necropsy of survivors performed: no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
other: concentration not given
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: no mortality observed
Mortality:
none
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
not performed

Any other information on results incl. tables

No mortality was observed when rats were exposed for up to 8 hours to an atmosphere that had been saturated at room temperature with the volatile part of the compound.

Applicant's summary and conclusion