Registration Dossier
Registration Dossier
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EC number: 203-729-4 | CAS number: 110-02-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: 3a: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals, Environ. Mol. Mutagen. 9(SUPPL.9):1-110
- Author:
- Zeiger,E, Anderson,B, Haworth,S, Lawlor,T, Mortelmans,K and Speck,W
- Year:
- 1 987
- Bibliographic source:
- CCRIS
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No further details
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Thiophene
- EC Number:
- 203-729-4
- EC Name:
- Thiophene
- Cas Number:
- 110-02-1
- Molecular formula:
- C4H4S
- IUPAC Name:
- thiophene
Constituent 1
Method
- Target gene:
- Histidine
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium TA 97
- Metabolic activation:
- with and without
- Metabolic activation system:
- RAT and HAMSTER, LIVER, S-9, AROCLOR 1254
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
The bacterial reverse mutation assay (Ames test) for thiophene was negative in all strains tested.
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