Registration Dossier
Registration Dossier
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EC number: 214-688-7 | CAS number: 1185-81-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Di-n-butyltin oxide was incubated in an aqueous solution including nutrients with an algae population of Scendesmus subspicatus for a test duration of 72 hours. The increase in biomass and growth rate of each concentration were compared to those of the controls, and the inhibition was calculated. The observed reduction in growth was not prominent and showed no concentration-dependence. It was therefore interpreted as not being substance-related. the biomass and growth rates could not be calculated. A saturated solution of di-n-butyltin oxide is not toxic to the green algae Scenedesmus subspicatus.
The EC50 of Scenedesmus subspicatus exposed to dibutyltin oxide was reported as >1.6 mg/L.
The study was performed to the OECD guideline 201.
As no toxicity to aquatic algae data are available for dibutylbis(dodecylthio)stannane this endpoint has been addressed by using a read across approach from dibutyltin dioxide.
Key value for chemical safety assessment
Additional information
Read-across between dibutyltin compounds concerning aquatic toxicity endpoints was considered appropriate as dibutyltin and octyltins are known, through industry, to hydrolyse rapidly in water and form, in the case of dibutyltins, dibutyltin oxide, and so on this basis, it is possible to read-across between the different dibutyltin compounds to address the Toxicity to aquatic algae and cyanobacteria endpoint. As no toxicity to aquatic algae data are available for dibutylbis(dodecylthio)stannane this endpoint has been addressed by using a read across approach from dibutyltin dioxide.
Reference: Steger-Hartmann T (1999) - Read-across from DBTO.
Reliability score and rationale: 2 (reliable with restrictions). Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results, however the study is being used for read-across purposes from a supporting substance.
Key value for chemical safety assessment
EC50/LC50 for freshwater algae: >1.6 mg/L
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