Registration Dossier
Registration Dossier
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EC number: 203-026-2 | CAS number: 102-36-3
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: limited documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
- Principles of method if other than guideline:
- 10 rats received 100 mg/kg 3,4-dichlorophenyl isocyanate per gavage on 14 consecutive working days
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,4-dichlorophenyl isocyanate
- EC Number:
- 203-026-2
- EC Name:
- 3,4-dichlorophenyl isocyanate
- Cas Number:
- 102-36-3
- Molecular formula:
- C7H3Cl2NO
- IUPAC Name:
- 1,2-dichloro-4-isocyanatobenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: oil - not further specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 working days
- Frequency of treatment:
- daily (on working days)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw/d
Basis:
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
no mortality, no clinical signs
Applicant's summary and conclusion
- Executive summary:
method: 10 rats received 100 mg/kg 3,4-dichlorophenyl isocyanate per gavage on 14 consecutive working days.
result: no mortality, no clinical signs
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