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Diss Factsheets
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EC number: 203-026-2 | CAS number: 102-36-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Phototransformation in air
Kloepffer, 1990
Using the Atkinson calculation method and assuming hydroxyl radicals as sensitizer for indirect photolysis (ensitiser concentration: 500000 molecule/cm³), the following results for 3,4-dichlorophenyl isocyanate were obtained:
Rate constant (for indirect photolysis): 0.00000000000075 cm³/(molecule*sec)
Degradation in % (for indirect photolysis): ca. 50 after 21 day(s)
Hydrolysis
There is no test on hydrolysis for 3,4-dichlorophenyl isocyanate available.
It is commonly known, that the reaction of isocyanates with water gives a carbamic acid as an unstable intermediate, which undergoes decarboxylation to produce carbon dioxide and the corresponding amine (see e.g. Clayden, 2009). Based on this process and due to the lack of data on hydrolysis properties, results from the hydrolysis study of the structural analogue 4-chlorophenyl isocyanate are used to describe the hydrolysis properties of 3,4-dichlorophenyl isocyanate. The chemical structures are closely related, the only difference consists in an additional chlorine substituent present in position 3 in the structure of 3,4-dichlorophenyl isocyanate.
A test comparable to guideline study (investigation on stability in aqueous test solutions) was performed in order to examine the stability under conditions simulating those in the environment (pH 7, presence of light and air). The results show that 4-chlorophenyl isocyanate hydrolyses rapidly, forming CO2 and 4-chloroaniline as primary hydrolysis products. Assuming a kinetic function of first order, a half life period of 7.3 h can be calculated (Bayer Industry services, 2004).
For 3,4-dichlorophenyl isocyanate the fast hydrolysis towards the product 3,4-dichloronaniline (95-76-1) is to be expected. For further details please refer to chapter 13.2.
Additional information
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