Registration Dossier
Registration Dossier
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EC number: 218-712-7 | CAS number: 2217-40-5
Endpoint summary
Administrative data
Description of key information
The median lethal dose of 1-Aminotetralin after oral administration was found to be greater than 300 mg/kg and less than 500 mg/kg body weight in rats (OECD 423).
Key value for chemical safety assessment
Additional information
The study was performed to assess the acute toxicity following oral administration of 1-Aminotetralin in Wistar rats. Single doses of 500 and 300 mg/kg body weight of test material preparations in olive oil Ph.Eur./DAB were given to three administration groups of three fasted female animals, each, (500 mg/kg in 3 females, 300 mg/kg in 6 females) by gavage in a sequential manner. Two animals of the 500 mg/kg administration group were found dead within 4 hours after application. No mortality occurred in the 300 mg/kg administration groups. During necropsy one animal that died in the 500 mg/kg administration group showed red erosion/ulcer in the glandular stomach. No macroscopic pathologic abnormalities were noted in the other animal that died (500 mg/kg: 1 female) and in the animals examined at the end of the observation period (500 mg/kg: 1 female; 300 mg/kg: 6 females). Under the conditions of this study the median lethal dose of 1-Aminotetralin after oral administration was found to be greater than 300 mg/kg and less than 500 mg/kg body weight in rats. [BASF, 2006]
Justification for classification or non-classification
Based on the available data the test item is subject to C&L:
according to Regulation 1272/2008/EC: acute oral tox. 4, H302 and
according to Directive 67/548/EEC: acute oral tox.: R22
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