Registration Dossier
Registration Dossier
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EC number: 287-401-6 | CAS number: 85507-79-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Older study conducted prior to the introduction of GLP and OECD test guidelines. Standard methods used but details of methods and results not available. For read-across justification see Section 13.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats given single doses of DUP of up to at least 15, 800 mg/kg bw. Animals observed for signs of toxicity.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diundecyl phthalate
- EC Number:
- 222-884-9
- EC Name:
- Diundecyl phthalate
- Cas Number:
- 3648-20-2
- Molecular formula:
- C30H50O4
- IUPAC Name:
- diundecyl benzene-1,2-dicarboxylate
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- Up to at least 15,800 mg/kg bw
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: minimum lethal dose
- Effect level:
- > 15.8 other: g/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No 95% confidence limits reported
- Mortality:
- No mortality
- Clinical signs:
- other: No significant toxic effects
- Gross pathology:
- No significant toxic effects
- Other findings:
- None reported
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study DUP is virtually non-toxic
- Executive summary:
The acute oral toxicity (LD50) of the substance in the rat is in excess of 15.8 g/kg body weight
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