Propyloxirane

Endpoint summary

Description of key information

not irritating to the skin (BASF AG, 1982, OECD404)
irritating to the eye (BASF AG, 1982, OECD405)

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not irritating)

Additional information

Skin irritation corrosion:

The potential of n-Pentenoxide-1,2 to induce skin irritation was tested according to OECD guideline 404. Three White Vienna rabbits were shaved and the appropriate skin sites treated with the test item for 4 h using semi-occlusive dressing. Rabbits were monitored for 8 days and the severity of skin lesions evaluated according to the Draize scoring system. The mean erythema score for the three rabbits after 24, 48 and 72 h was 0.67 and the edema score 0.1. Erythema was fully reversible within 48 h (2 animals) or 8 days (1 animal), respectively. Accordingly, edema was fully reversible within 24 h (2 animals) or 48 h, respectively. No other clinical findings (including organ changes) were observed by the end of the treatment. It can therefore be concluded that 1,2 -Pentenoxid is not irritating.

Eye irritation/corrosion:

The potential of n-Pentenoxide-1,2 to induce eye irritation/corrosion was analyzed according to OECD guideline 405. One eye of three White Vienna rabbits was treated with 100 µl of the undiluted test item; the untreated eyes served as controls. Substance was not washed out the next day. Rabbits were observed for 8 days and eye lesions recorded according to the Draize scheme. The following mean scores for the three animals were noted after (mean score for 24, 48 and 72 h readings):

Cornea score: 0.67 (fully reversible within 8 days; however, for 2 of 3 animals, the mean score after 24, 48 and 72 h was 1)

Iris score: 0

Conjunctivae score: 1.57 (fully reversibly within 8 days)

Chemosis Score: 0.33 (fully reversible within 72 h)

Due to the mean cornea score which is >= 1 in 2 of 3 rabbits, but fully reversible within eight days, the substance has to be classified as irritating to the eyes.

Justification for selection of skin irritation / corrosion endpoint:
No skin irritating monitored in an OECD guideline 404 study

Justification for selection of eye irritation endpoint:
Moderate skin irritation observed in 2 of 3 rabbits in an OECD guideline 405 study

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

According to the classification criteria laid down in Council Directive 67/548/EEC (and subsequent adaptations) the test substance does not require skin and eye classification.

However, according to Regulation (EC) No 1272/2008 (CLP), the test item does not require skin labelling but is classified as eye category 2 and labelled with "Warning" and H319.