Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-701-3 | CAS number: 1003-14-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study (OECD 403)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Propyloxirane
- EC Number:
- 213-701-3
- EC Name:
- Propyloxirane
- Cas Number:
- 1003-14-1
- Molecular formula:
- C5H10O
- IUPAC Name:
- 2-propyloxirane
- Details on test material:
- - Name of test material (as cited in study report): n-Pentenoxid-1,2
- Physical state: colourless, liquid
- Analytical purity: 90%
- Stability under test conditions: Stability was ensured for at least the study period
- Storage condition of test material: was stored at room temperature excluded from air
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH
- Age at study initiation: 8-9 weeks
- Weight at study initiation: mean(males): 272 +/- 13.8 g, mean(females): 184 +/- 12.0 g
- Housing: 5 animals/cage
- Diet: KLIBA rat/mouse laboratory diet 24-343-4 10 mm pellets (Klingentalmuehle AG) ad libitum (during the post-exposure observation period)
- Water: ad libitum (during the post-exposure obeservation period)
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Whole-body inhalation system: IKA 02 (glass-steel construction)
- Exposure chamber volume: 200 L
- Source and rate of air: continuous infusion pump INFU 362 (INDIGEN/Switzerland), 3000 L/h
- Method of conditioning air: The blast air was conditioned via a central air-conditioning system
- System of generating particulates/aerosols: glass vaporizer with thermostat (By means of the continuous infusion pump amounts of the test substance per test group were supplied to the heated vaporizer (40°C). The vapors that developed were mixed with supply air and passed into the inhalation system).
- Temperature and pressure: 19-25°C, -10 - -17 Pa
TEST ATMOSPHERE
- Brief description of analytical method used: Sampling: Apparatus: 3 fritted glass flasks, connected in series, filled with sorption solvent (DMF). Two fritted glass flasks were analysed for each sample. The third fritted glass flask was used to control the effectiveness of the sorption for all samples of a test group and was analyzed separately. For the quantitative determination of the vapor concentration a gas chromatographical method was used.
- Samples taken from breathing zone: yes
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- The nominal concentration was calculated from the amount of substance consumed and the air flow.
- Duration of exposure:
- 4 h
- Concentrations:
- - means: 5.3, 10.6, 21.3 mg/L (nominal: 5.6, 11.4, 23.1 mg/L)
- No. of animals per sex per dose:
- 5
- Control animals:
- other: historical control data used for the body weight development
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: - clinical findings: several times during exposure and at least once on each workday in the observation period; -check for dead animals: daily; -weighing: before the beginning of the test, after 7 days and at the end of the observation period;
- Necropsy of survivors performed: yes - Statistics:
- The statistical evaluation of the dose-response relationship was carried out using FORTRAN program AKPROZ. Depending on the data of the dose-response relationship obtained by way of experiment, this program is used to estimate the LC50 or to perform a Probit analysis. Estimation of the LC50 will produce types LC50 greater, LC50 about, or LC50 smaller. If the results are Type LC50 greater or LC50 smaller, an additional binominal test will be carried out to verify these statements statistically, if necessary.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 10.6 - < 21.3 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: statistical evaluation; 10.6 mg/L: the statistical reliability is 99%; 21.3 mg/L: the statistical reliability is 90%;
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 18 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: statistical evaluation
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- ca. 18 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: statistical evaluation
- Mortality:
- - test group 1 (5.3 mg/L): 0/10; - test group 2 (10.6 mg/L): 0/10; - test group 3 (21.3 mg/L): 8/10 (4 males, 4 females); the animals died either on the day of exposure or one day after exposure
- Clinical signs:
- other: - during exposure in all test groups: accelerated respiration (30/30 at the end of the 4 hrs exposure), eyelid closure (30/30 at the end of the 4 hrs exposure), ruffled fur (30/30 at the end of the 4 hrs exposure), wiping of snouts, restlessness; - durin
- Body weight:
- The body weight gain of male and female rats in the test groups 1 and 2 and female rats in the test group 3, compared with a historical control collective, was not affected by the substance over the total observation period. The body weight gain of male rats in the test group 3, compared with a historical control collective, was retarded in the first week of the observation period and adjusted to normal in the second week of the observation period.
- Gross pathology:
- - dead animals of test group 3: general congestion; lungs: focal hyperemia with edema and areas with emphysema, thorax: slight hydrothorax; - sacrificed animals: no pathological findings noted
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.