Registration Dossier

Administrative data

Endpoint:
in vitro gene mutation study in mammalian cells
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only a one page summary of the results is available, no details on experimental set-up given; no information about positive and negative controls

Data source

Reference
Reference Type:
secondary source
Title:
BORANE-TETRAHYDROFURAN COMPLEX
Bibliographic source:
National Institutes of Health, CCRIS data base

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Type of assay:
mammalian cell gene mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Test concentrations with justification for top dose:
7.3-15 mL/mL
Vehicle / solvent:
Vehicle: ethanol
Details on test system and experimental conditions:
L5178Y (TK+/TK-) were used and incubated with the test substance with and withou metabolic activation (S9)

Results and discussion

Test results
Species / strain:
mouse lymphoma L5178Y cells
Metabolic activation:
with and without
Genotoxicity:
positive
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion