Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in mammalian cells
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only a one page summary of the results is available, no details on experimental set-up given; no information about positive and negative controls

Data source

Reference
Reference Type:
secondary source
Title:
BORANE-TETRAHYDROFURAN COMPLEX
Bibliographic source:
National Institutes of Health, CCRIS data base

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Type of assay:
mammalian cell gene mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrahydrofuran-borane
EC Number:
237-881-8
EC Name:
Tetrahydrofuran-borane
Cas Number:
14044-65-6
Molecular formula:
C4H11BO
IUPAC Name:
Borane-tetrahydrofuran (1:1)

Method

Test concentrations with justification for top dose:
7.3-15 mL/mL
Vehicle / solvent:
Vehicle: ethanol
Details on test system and experimental conditions:
L5178Y (TK+/TK-) were used and incubated with the test substance with and withou metabolic activation (S9)

Results and discussion

Test results
Species / strain:
mouse lymphoma L5178Y cells
Metabolic activation:
with and without
Genotoxicity:
positive
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion