Registration Dossier
Registration Dossier
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EC number: 218-561-7 | CAS number: 2182-55-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1964-06-16 to 1964-06-29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-standard study. Non-GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- Principles of method if other than guideline:
- BASF-test
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- (vinyloxy)cyclohexane
- EC Number:
- 218-561-7
- EC Name:
- (vinyloxy)cyclohexane
- Cas Number:
- 2182-55-0
- Molecular formula:
- C8H14O
- IUPAC Name:
- (ethenyloxy)cyclohexane
- Test material form:
- other: colorless liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Hannover
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age: young adult
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aqueous emulsion with tragacanth
- Details on exposure:
- Form of administration: 1 - 2% aqueous emulsion with tragacanth
Route of aciministration: Intraperitoneal - Doses:
- 1600, 200, 160, 125, 100, 50 mg/kg bw
- No. of animals per sex per dose:
- 10 (5 males and 5 females) per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 0.11 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: corresponding to a LD50 of 98 mg/kg bw assuming a density of 0.89 g/mL of the test item
- Mortality:
- After 14 days observation period, the dead rate was as follows:
1600 mg/kg bw: 10/10
200 mg/kg bw: 7/10
160 mg/kg bw: 8/10
125 mg/kg bw: 7/10
100 mg/kg bw: 1/10
50 mg/kg bw: 2/10 - Clinical signs:
- Staggering, dyspnea and narcosis; convulsions and late deaths
- Body weight:
- No data
- Gross pathology:
- No abnormalities detected
- Other findings:
- No data
Applicant's summary and conclusion
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