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EC number: 231-293-5 | CAS number: 7486-38-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP, short documentation, purity not specified, similar to TG471
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
- Reference Type:
- publication
- Title:
- Bacterial mutagenicity testing of 49 food ingredients gives very few positive results.
- Author:
- Prival MJ, Simmon VF, Mortelmans KE
- Year:
- 1 991
- Bibliographic source:
- Mutat. Res. 260, 321-329.
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Principles of method if other than guideline:
- The standard S. typhimurium plate-incorporation assay was performed. The S9 mix used as an in vitro metabolic activator system contained 10% Aroclor 1254-induced liver S9 from male Sprague-Dawley rats. Each substance was tested in the presence and in the absence of S9 mix. In addition the tryptophan requiring E. coli strain WP2 was tested for reversion to tryptophan independance. This test was performed by the same procedure as the S. typhimurium assay except that agar was supplemented with Oxoid nutrient broth to provide a trace of tryptophan. All platings were performed in duplicates and all tests were repeated on a different day. Concurrent positive controls were run with each test. The results were considered valid only if the positive control compound induced increase in mutant counts to at least twice background. The following positive control compounds were used in the absence of S9: 2-nitrofluorene (5 or 10 µg per plate) for S. typhimurium strains TA98 and TA1538; sodium azide (0.5 or 1 µg) for TA100 and TA1535; 9-aminoacridine (50 or 100 µg) for TA1537; and AF-2 (furylframide, 0.1 µg) or N-methyl-N'-nitro-N-nitrosoguanidine (ENNG) (10 µg) for E. coli. 2-Anthramine (1 to 10 µg) was the positive control compound requiring S9 metabolic activation used for all bacterial strains.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Adipic acid
- EC Number:
- 204-673-3
- EC Name:
- Adipic acid
- Cas Number:
- 124-04-9
- Molecular formula:
- C6H10O4
- IUPAC Name:
- adipic acid
- Details on test material:
- Test substance: purity not specified
Constituent 1
Method
- Target gene:
- S. typhimurium TA 1535, TA 1537, TA 1538, TA 98, TA 100: histedine synthesis; Escherichia coli WP2 : tryptophan synthesis
Species / strain
- Species / strain / cell type:
- other: S. typhimurium TA 1535, TA 1537, TA 1538, TA 98, TA 100, and Escherichia coli WP2
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 0.033, 0.10, 0.33, 1.0, 3.3 and 10 mg/plate
- Details on test system and experimental conditions:
- IUCLID4 Type: Ames test
Results and discussion
Test results
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: other: S. typhimurium TA 1535, TA 1537, TA 1538, TA 98, TA 100, and Escherichia coli WP2
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Adipic acid gave no evidence of mutagenicity in any of the
bacterial strains used. Negative and positive controls were functional.
Applicant's summary and conclusion
- Executive summary:
Adipic acid was neither mutagenic nor cytotoxic in a study similar to OECD TG 471 in bacteria such as Salmonella typhimurium strains TA98, TA100, TA1535, TA1537 and TA1538 or Escherichia coli WP2 up to concentrations of 10 mg/plate with or without metabolic activator S9 (Prival 1991).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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