Registration Dossier
Registration Dossier
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EC number: 938-458-7 | CAS number: 1443751-77-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a dermal sensitisation study according to OECD TG 406, 1992) with Amides, C8-10, N-(hydroxyethyl) in sesame oil, young adultDunkin-Hartleyguinea pigs were tested using the Maximization test method. Positive control substance was α-hexyl cinnamic aldehyde, 85% with a sensitisation rate of 100 %.
Moderate skin reactions were observed after intradermal induction (0.5 %) and dermal induction (75 %) in the test substance animals. After challenge exposure (1 %) no skin reactions were observed in test or control animals at any observation time. Therefore the sensitisation rate was 0 %.
For the challenge concentration, which is the highest non-irritant dose, 1 % of the test item was used.
In this study, Amides, C8-10, N-(hydroxyethyl), is not a dermal sensitiser.
Migrated from Short description of key information:
Guinea pig maximisation test (OECD 406): not sensitising
Justification for classification or non-classification
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