Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 220-863-9 | CAS number: 2921-57-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- grey literature
- Title:
- Methylprednisolone, Summary Report (2001)
- Author:
- European Medicines Agency (EMEA), The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines Evaluation Unit, Committee for Veterinary Medicinal Products
- Year:
- 2 001
- Bibliographic source:
- HSDB data base; http://www.emea.europa.eu/pdfs/vet/mrls/079801en.pdf
Materials and methods
- Principles of method if other than guideline:
- Guideline not available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methylprednisolone
- EC Number:
- 201-476-4
- EC Name:
- Methylprednisolone
- Cas Number:
- 83-43-2
- Molecular formula:
- C22H30O5
- IUPAC Name:
- 11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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