Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Material tested is in a naptha solution and the toxicity evaluated is based on a SG of DFDPM of 0.8g/ml and all deaths are concluded as being due to the DFDPM not the solvent.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: O.E.C.D. Short term and long term tox groups, final report, Paris 1981; ISBN 92-64-12221-4
GLP compliance:
not specified
Test type:
acute toxic class method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Details on oral exposure:
Directly down a catheter into the lumen of the stomach
Doses:
2-5ml/kg
No. of animals per sex per dose:
4 groups of five males and five females
Control animals:
not specified
Details on study design:
O.E.C.D. Short term and long term toxicology groups, final report, Paris 1981; ISBN 92-64-12221-4

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 3.8 mL/kg bw
Based on:
test mat.
95% CL:
>= 3.1 - <= 4.6
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 2.8 mL/kg bw
Based on:
test mat.
95% CL:
>= 2.2 - <= 3.5
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 3.3 mL/kg bw
Based on:
test mat.
95% CL:
>= 2.8 - <= 3.8

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information Hodge an Sterner 1949 Criteria used for interpretation of results: expert judgment
Conclusions:
Classified as Harmful