Registration Dossier
Registration Dossier
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EC number: 907-495-0 | CAS number: 198028-14-7
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Two chronic toxicity studies on Daphnia Magna are available on the registered test item according to the TG OECD 211 under WAF conditions.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- > 1.6 mg/L
Additional information
As the test substance is highly insoluble (0.02 mg/L, at 25°C in a WoE based on calculation), therefore WAF solutions were prepared and result analyses were based on initial loading rates.
The first study (Wang Lei, 2013) was performed under China GLP with analytics under WAF conditions with standard medium (Elendt M7). Under semi-static conditions of 72 h-renewal, no significant effects on the mortality and reproduction of Daphnia Magna exposed to the test substance were observed (NOEL > 1.6 mg/L).
A second supporting study was used (Doig C., 2014) and was performed under GLP, no effects on reproduction were observed at the highest test item concentration NOELr > 20 mg/L. Analytical verification of test concentrations was not conducted during this study as it was not possible to develop a suitably sensitive analytical method for the analysis of test item in Elendt M4 medium. Results throughout this report are therefore based on initial loading rates.
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