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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
2.1
Temp.:
40 °C
Remarks on result:
other: pH not reported
Conclusions:
The partition coefficient (1-octanol / water) of 2 -chloro-5-chloromethylpyridine was determined as logPow = 2.1.
Executive summary:

The partition coefficient (1-octanol/water) of 2 -chloro-5-chloromethylpyridine (CCMP) was determined according to OECD 117 guideline and EEC-guideline 92/69/EWG A.8, HPLC-method. Therefore, 9

neutral calibration substances were injected into a HPLC-system under the same analytical conditions (column temperature 40°C) as the test item. A calibration curve was created by using the measured retention times and the known log Pow-values of the calibration substances for linear regression.

From the resulted calibration curve and its equation the log Pow of the substance had been interpolated. The partition coefficient (1-octanol / water) of 2 -chloro-5-chloromethylpyridine was determined as logPow = 2.1.

Description of key information

The partition coefficient (1-octanol/water) of 2 -chloro-5-chloromethylpyridine (CCMP) was determined according to OECD 117 guideline and EEC-guideline 92/69/EWG A.8, HPLC-method. Therefore, 9

neutral calibration substances were injected into a HPLC-system under the same analytical conditions (column temperature 40°C) as the test item. A calibration curve was created by using the measured retention times and the known log Pow-values of the calibration substances for linear regression.

From the resulted calibration curve and its equation the log Pow of the substance had been interpolated. The partition coefficient (1-octanol / water) of 2 -chloro-5-chloromethylpyridine was determined as logPow = 2.1.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.1
at the temperature of:
25 °C

Additional information

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