2-butyloctan-1-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

October until November 1986

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Report date:

1986

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-butyloctan-1-ol

EC Number:

223-470-0

EC Name:

2-butyloctan-1-ol

Cas Number:

3913-02-8

Molecular formula:

C12H26O

IUPAC Name:

2-butyloctan-1-ol

Details on test material:

- Name of test material (as cited in study report): Isofol 12
- specific gravity: 0.845 g/l
no more details mentioned

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Lippische Versuchstierzucht, Extertal, Germany
- Age at study initiation: 52 - 60 days
- Weight at study initiation: 156 - 168 g
- Fasting period before study: 15 - 16 hours
- Housing: single in Macrolon cages (type III)
- Diet : ALTROMIN 1324 (ad libitum)
- Water: tap water (ad libitum)

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21° ± 1
- Humidity (%): 55 ± 5
- Air changes (per hr): not mentioned
- Photoperiod (hrs dark / hrs light): 12/12

IN-LIFE DATES: From: October 1986 To: November 1986

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 47.9 ml/kg bw
single application by gavage

Doses:

10225 / 15041 / 22055 / 32363 / 39208 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, bodyweight and fodder consumption were determined

Statistics:

no

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

26 533 mg/kg bw

Effect levels 2

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

37 434 mg/kg bw

Mortality:

Time of death: 8-24 h after dosing at the earliest and 3 days after dosing at the latest.

Clinical signs:

other: The signs were observed: reduced motility, hypopnoeam, reduced food consumption (15041 mg/kg), pultaceous faeces (22055 mg/kg), dyspnoea (32363 mg/kg). Surviving animals recovered within 2 - 3 days after administration.

Gross pathology:

Post mortem dissection revealed cloudy bright liver, redness intestine. Dissection of surviving animals at the end of the experiment observed none pathology findings.

Any other information on results incl. tables

Table 1: Number of animals dead [and with evident toxicity] [and time range within which mortality occurred]

 

Dose (mg/kg bw)	Mortality (# dead/total)			Time range of deaths	Number with evident toxicity (#/total)
	Male	Female	Combined		Male	Female	Combined
10225	0/5	0/5	0/10	-	0/5	0/5	0/10
15041	0/5	3/5	3/10	8 - 30 h	5/5	2/2	7/7
22055	1/5	3/5	4/10	1 - 2 d	4/4	2/2	6/6
32363	1/5	4/5	5/10	1 - 3 d	4/4	1/1	5/5
39208	2/5	3/5	5/10	8 h - 2 d	3/3	2/2	5/5

 

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

2-Butyloctan-1-ol is practically nontoxic after oral administration to rats with an LD50 of 26533 mg/kg bw for females and 37434 mg/kg bw for males.

Executive summary:

2-Butyloctan-1-ol is practically nontoxic after oral administration to rats with an LD50 of 26533 mg/kg bw for females and 37434 mg/kg bw for males.