Registration Dossier
Registration Dossier
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EC number: 241-793-5 | CAS number: 17832-28-9
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
No carcinogenicity study available.
4 -(vinyloxy)butan-1 -ol (Hydroxy butyl vinyl ether , HBVE), isobutyl vinyl ether (IBVE, CAS 109 -53 -5), methyl vinyl ether (MVE; CAS 107 -25 -5), and ethyl vinyl ether (EVE, CAS 109-92-2) were not mutagenic in the Ames test or in mammalian cell systems (IBVE, EVE, HBVE) both in the absence and presence of metabolic activation. IBVE, EVE and HBVE did not induce chromosomal aberrations in Chinese Hamster cells. In vivo, MVE did not induce micronuclei in bone marrow of mice. The members of this category appear to have no potential to induce gene mutations or chromosomal aberrations.
HBVE is practically exclusively used as intermediate in the manufacture of vinyl ether polymers and co-polymers.
Worker exposure to HBVE is controlled by the use of closed systems, industrial hygiene controls, and personal protective equipment. Potentially existing residual HBVE is expected to evaporate during the process of heat-treatment. Therefore, no exposure of the general population is expected. Taking into account the lack of genotoxic effects, it is concluded that carcinogenicity should not be an endpoint of concern.
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