Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 229-861-2 | CAS number: 6790-58-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no hazard identified
Marine water
- Hazard assessment conclusion:
- no hazard identified
STP
- Hazard assessment conclusion:
- no hazard identified
Sediment (freshwater)
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Sediment (marine water)
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential to cause toxic effects if accumulated (in higher organisms) via the food chain
Additional information
Justification for Read-across:
Please refer to the justification document attached to section 13.
Environmental fate and pathways:
The registered substance, (-)-(3aR,5aS,9aS,9bR)-3a,6,6,9a-Tetramethyldodecahydronaphtho[2,1-b]furan, contains no organic functional groups that may hydrolyse under environmental condition like alkyl halides, amides, amines, epoxides, esters. This substance consists only of organic functional groups that are relatively or completely inert with respect of hydrolysis. Based on the chemical structure an estimation of the hydrolysis rate is not possible. This statement is supported by one study showing that the registered substance is hydrolytically stable under the conditions of the test (the disappearance of the substance after 5 days as well as after 28 days is less than 10% at any pH (from 2 to 12) at 40°C).
Based on the key biodegradation study, the registered substance is readily biodegradable and therefore is not considered persistent in the environment. Finally, based on data on a source substance (which is the racemic form of the registered substance), (±)-(3aR*,5aS*,9aS*,9bR*)-3a,6,6,9a-Tetramethyldodecahydronaphtho[2,1-b]furan , the adsorption coefficient (Koc) of the registered substance can be determined at 5250, corresponding to a log Koc at 3.72. The result indicates that the registered substance is environmentally immobile in soils, according to P.J. McCall et al., 1980. Based on structural similarity and common physico-chemical properties between these isomers, this source substance is considered adequate for read-across purposes (see IUCLID section 13 for justification).
Aquatic toxicity:
The aquatic toxicity of the registered substance, was assessed using data performed on the registered substance and on source substance (stated above). Based on structural similarity and common physico-chemical properties between these isomers, and the same results on the observed toxicity to aquatic invertebrates (no acute effect up to the attainable limit of solubility in test medium, see ECHA disseminated dossier of the read-across substance EC# 223 -118 -6), this source substance is considered adequate for read-across purposes.
No toxic effects were observed up to the attainable limit of solubility of the registered and/or supporting substances in acute studies for the three aquatic trophic levels (fish, aquatic invertebrates and algae) and no long-term effect was observed in the algae study at the maximum attainable mean test concentration. Therefore, based on a read-across approach, the registered substance is not expected to be hazardous to pelagic organisms. The chemical safety assessment for environment is not necessary.
In accordance with column 2 of REACH Annex VIII, the activated sludge respiration inhibition test does not need to be conducted because the substance is readily biodegradable, according to the OECD 301F study. The applied test concentrations (100 mg/L) are in the range of concentrations that can be expected in the influent of a sewage treatment plant, and no inhibition effects on the activity of microorganisms was observed.This statement is supported by one study, performed on the registered substance, according to DIN Guideline 38412 part 27 with GLP statement. The test substance had no inhibitory effect on the respiration rate of Pseudomonas putida after the incubation period of 30 min at the test item concentration of 10 g/L.
Conclusion on classification
No acute toxic effects were observed on all trophic levels at or even close to the water solubility of the substance and no chronic effect was observed in the algae study at the maximum attainable mean test concentration.
The substance is readily biodegradable meeting the 10-day window criterion.
Classification according to the Annex I of the Regulation (EC) No 1272/2008 (CLP): The substance is NOT classified for the environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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