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Vapour pressure

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vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 2013-06-12 to 2013-07-05
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Substance ID is adequately specified with purity. Therefore full validation applies.
according to guideline
OECD Guideline 104 (Vapour Pressure Curve)
according to guideline
EU Method A.4 (Vapour Pressure)
GLP compliance:
yes (incl. QA statement)
Inspected on 10 July 2012 / Signed on 30 November 2012
Type of method:
gas saturation method
Key result
25 °C
Vapour pressure:
0.066 Pa
Remarks on result:
other: interpolated

Average of vapor pressure (mean of three determinations (three flow rates)):

66.1 mPa at 25°C

221 mPa at 35°C

688 mPa at 45°C

Detailed data, the vapor pressure curve and the regression parameters are provided in the experimental report.


The linearity of the detector response with respect to concentration was assessed over the concentration range of 21.6 to 540 mg/L (n=7). This was satisfactory with a correlation coefficient of 1.000 being obtained.

Concentrations of sample solutions from traps 1 range between 29 and 200 mg/L (no substance detected in traps 2), therefore within the calibration range.


To ensure saturation control, three different flow rates were used at each temperature. From the data, it can be clearly seen that higher flow rates did not lead to lower vapor pressures, which means that the nitrogen was saturated with test item under the conditions of the test.

Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, gas saturation method. Determinations were conducted at 25, 35 and 45°C, with three flow rates per temperature. Mass of evaporated test item was quantified by GC. Vapor pressure at 25°C was interpolated from the regression to be 0.066 Pa.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:
0.066 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study. The result is retained as key data for purpose of CSA.