Registration Dossier
Registration Dossier
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EC number: 205-355-7 | CAS number: 139-13-9
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- No information
- Author:
- Anonymous
- Year:
- 2 000
- Bibliographic source:
- IUCLID4 data set for trisodiumnitrilotriacetate, 18 February 2000, page 246
Materials and methods
Test guideline
- Guideline:
- other: no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nitrilotriacetic acid
- EC Number:
- 205-355-7
- EC Name:
- Nitrilotriacetic acid
- Cas Number:
- 139-13-9
- Molecular formula:
- C6H9NO6
- IUPAC Name:
- 2-[bis(carboxymethyl)amino]acetic acid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
Administration / exposure
- Route of administration:
- oral: drinking water
- Duration of treatment / exposure:
- from day 6 to day 18 of gestation
- Frequency of treatment:
- continuous
- Duration of test:
- 18 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.2% (300 mg/kg bw per day) as the acid
Basis:
nominal in water
- Control animals:
- yes, concurrent no treatment
Results and discussion
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Details on embryotoxic / teratogenic effects:
Teratogenic investigations were combined with a series of distribution experiments to follow nitrilotriacetic acid (NTA) within dam and fetus by
means of radio labelled NTA. NTA exerted no embryotoxic effect and produced no malformations though there was appreciable placental passage of radioactivity onto the fetus.
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- > 300 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Substance is NOT a potential developmental toxicant
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