Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1963
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No GLP, no guideline followed, not enough data to complete a full IUCLID record.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1963
Report Date:
1963

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of the test substance: Bis-(3-aminopropyl-9methylamine, no further data.

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
The mice were applied with 21 5 solution of teh test substance
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
90 other: mm³
Based on:
test mat.
Remarks on result:
other: Equivalent to 0.09 mL/kg bw, obtained in mice with pH 11 21 % test solution.
Sex:
not specified
Dose descriptor:
LD50
Effect level:
450 other: mm³
Remarks on result:
other: quivalent to 0.45 mL/kg bw, obtained in mice with pH 7 21 % test solution

Any other information on results incl. tables

Symptoms observed: agitation, staggering, shortness of breath, cramps

In autopsy: following application of teh basic test substance solution, corrosion of the peritoneaum was observed.

Applicant's summary and conclusion