Sulfuric acid, mono-C12-14-alkyl esters, potassium salts

Short-term toxicity to aquatic invertebrates

Description of key information

48h EC50 (Daphnia magna) = 4.7 mg/L (nominal concentration, EG Guideline 92/69/EWG)
48h LC50 (Artemia salina) = 3.15 mg/L (nominal concentration, marine water)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

4.7 mg/L

Marine water invertebrates

Marine water invertebrates

Effect concentration:

3.15 mg/L

Additional information

Since no reliable short-term test involving aquatic invertebrates is available for C12-14AS K (CAS 1268005-68-0), in accordance to Regulation (EC) 1907/2006 Annex XI, 1.5, a read-across to another structurally related category members was conducted. Read-across data from the following substances were used: two C12-14 mixtures: C12-14AS Na (CAS 85586-07-8) and C12-14AS TEA (CAS 90583-18-9) and also two pure homologues: C12AS Na (CAS 151-21-3) and C14AS Na (CAS 1191-50-0). Toxicity of alkyl sulfates is dependent on the carbon chain length and the influence of the counter ion can be neglected.

The key, GLP study is available for C12-14AS Na (CAS 85586-07-8) according to EG Guideline 92/69/EWG. In this study Daphnia magna was exposed in a static system to five concentrations up to 10 mg/L (nominal concentration corresponding to 9.5 mg/L of measured concentration) of C12-14AS Na of 29.8% purity (in water). The 48-hour EC50 value of 4.7 mg a.i./L (nominal concentration) could be determined. Composition of carbon chains of the tested category member C12-14AS Na (CAS 85586-07-8) is the same as of C12-14AS K (CAS 1268005-68-0): both contain on average 58.1% of C12 and 32.6% of C14 chains. Due to structural and property similarity with the tested category member, the 48-hour EC50 value of 4.7 mg/L is considered as a reliable for C12-14AS K (CAS 1268005-68-0).

One reliable study investigating toxic effects of C12-14AS TEA (CAS 90583-18-9) to Daphnia magna is available. The GLP study was performed according to DIN 38412, part 1, equivalent to OECD 202 (Scholz 1995). Inhibition of mobility of daphnids caused by the test substance was determined after 24 and 48 of static exposure to test substance up to 10 mg/L (nominal concentrations in agreement with measured concentration). The results showed that the 48-hour EC50 value was 7.1 mg a.i./L (nominal concentration).

In a non-GLP test Ceriodaphnia dubia was exposed to six test concentrations of C12AS Na (CAS 151-21-3) up to 101 mg/L (Lauth 1996). The test was performed under flow-through conditions, no special guideline was followed. Mortality of daphnids was evaluated daily; the EC50 value determined after 48 hours of exposure was 5.55 mg/L. Furthermore, a non-GLP study with CAS 151-21-3 using a common marine species Artemia salina is available. In this static test mortality of Artemia was determined in culture dishes using six concentrations of test substance up to 18 mg/L (nominal concentrations). The LC50 value after 48 hours of exposure ranged between 3.15 and 3.8 mg/L (nominal concentration). Finally, a supporting study with C14AS Na (CAS 1191-50-1) is available. Ceriodapnia dubia was exposed to six concentrations up to 6.38 mg/L. Mortality of daphnids was checked daily. The 48-hour LC 50 value was 1.58 mg/L.